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Antisense Oligonucleotides Immobilized on Silicon-Organic Nanoparticles as a Tool for Prolonged Correction of Hypertensive States. / Levina, A. S.; Repkova, M. N.; Klimov, L. O. et al.

In: Bulletin of Experimental Biology and Medicine, Vol. 167, No. 1, 15.05.2019, p. 116-119.

Research output: Contribution to journal › Article › peer-review

Harvard

Levina, AS, Repkova, MN, Klimov, LO, Ryazanova, MA, Markel, AL & Zarytova, VF 2019, 'Antisense Oligonucleotides Immobilized on Silicon-Organic Nanoparticles as a Tool for Prolonged Correction of Hypertensive States', Bulletin of Experimental Biology and Medicine, vol. 167, no. 1, pp. 116-119. https://doi.org/10.1007/s10517-019-04473-5

APA

Levina, A. S., Repkova, M. N., Klimov, L. O., Ryazanova, M. A., Markel, A. L., & Zarytova, V. F. (2019). Antisense Oligonucleotides Immobilized on Silicon-Organic Nanoparticles as a Tool for Prolonged Correction of Hypertensive States. Bulletin of Experimental Biology and Medicine, 167(1), 116-119. https://doi.org/10.1007/s10517-019-04473-5

Vancouver

Levina AS, Repkova MN, Klimov LO, Ryazanova MA, Markel AL, Zarytova VF. Antisense Oligonucleotides Immobilized on Silicon-Organic Nanoparticles as a Tool for Prolonged Correction of Hypertensive States. Bulletin of Experimental Biology and Medicine. 2019 May 15;167(1):116-119. doi: 10.1007/s10517-019-04473-5

Author

Levina, A. S. ; Repkova, M. N. ; Klimov, L. O. et al. / Antisense Oligonucleotides Immobilized on Silicon-Organic Nanoparticles as a Tool for Prolonged Correction of Hypertensive States. In: Bulletin of Experimental Biology and Medicine. 2019 ; Vol. 167, No. 1. pp. 116-119.

BibTeX

@article{b11a1fa6aa46427585c1b4b343500c1f,
title = "Antisense Oligonucleotides Immobilized on Silicon-Organic Nanoparticles as a Tool for Prolonged Correction of Hypertensive States",
abstract = "We propose an original method for controlling BP by administration of Si~ODN nanocomposites containing antisense oligonucleotides fixed on silicon-organic nanoparticles. ODN in nanocomposites are targeted to mRNA of the genes encoding angiotensin-converting enzyme (ACE1) and type 1 angiotensin-II receptor (AT1A). The experiments were performed on hypertensive ISIAH rats, a genetic model of hypertension. Single inhalation or intraperitoneal administration of the nanocomposites targeted to ACE1 mRNA or ATA1 mRNA, respectively, led to a pronounced decrease (by ~30 mm Hg) in systolic BP in ISIAH rats over a week. The use of scrambled ODN in the nanocomposites had no effect. A decrease in the expression of ACE1 and AT1A genes under the effect of the corresponding antisense ODN was demonstrated, which attested to directed effect of the test preparations.",
keywords = "antisense oligonucleotides, arterial hypertension, nanocomposites, silicon-organic nanoparticles, RNA",
author = "Levina, {A. S.} and Repkova, {M. N.} and Klimov, {L. O.} and Ryazanova, {M. A.} and Markel, {A. L.} and Zarytova, {V. F.}",
year = "2019",
month = may,
day = "15",
doi = "10.1007/s10517-019-04473-5",
language = "English",
volume = "167",
pages = "116--119",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "1",

}

RIS

TY - JOUR

T1 - Antisense Oligonucleotides Immobilized on Silicon-Organic Nanoparticles as a Tool for Prolonged Correction of Hypertensive States

AU - Levina, A. S.

AU - Repkova, M. N.

AU - Klimov, L. O.

AU - Ryazanova, M. A.

AU - Markel, A. L.

AU - Zarytova, V. F.

PY - 2019/5/15

Y1 - 2019/5/15

N2 - We propose an original method for controlling BP by administration of Si~ODN nanocomposites containing antisense oligonucleotides fixed on silicon-organic nanoparticles. ODN in nanocomposites are targeted to mRNA of the genes encoding angiotensin-converting enzyme (ACE1) and type 1 angiotensin-II receptor (AT1A). The experiments were performed on hypertensive ISIAH rats, a genetic model of hypertension. Single inhalation or intraperitoneal administration of the nanocomposites targeted to ACE1 mRNA or ATA1 mRNA, respectively, led to a pronounced decrease (by ~30 mm Hg) in systolic BP in ISIAH rats over a week. The use of scrambled ODN in the nanocomposites had no effect. A decrease in the expression of ACE1 and AT1A genes under the effect of the corresponding antisense ODN was demonstrated, which attested to directed effect of the test preparations.

AB - We propose an original method for controlling BP by administration of Si~ODN nanocomposites containing antisense oligonucleotides fixed on silicon-organic nanoparticles. ODN in nanocomposites are targeted to mRNA of the genes encoding angiotensin-converting enzyme (ACE1) and type 1 angiotensin-II receptor (AT1A). The experiments were performed on hypertensive ISIAH rats, a genetic model of hypertension. Single inhalation or intraperitoneal administration of the nanocomposites targeted to ACE1 mRNA or ATA1 mRNA, respectively, led to a pronounced decrease (by ~30 mm Hg) in systolic BP in ISIAH rats over a week. The use of scrambled ODN in the nanocomposites had no effect. A decrease in the expression of ACE1 and AT1A genes under the effect of the corresponding antisense ODN was demonstrated, which attested to directed effect of the test preparations.

KW - antisense oligonucleotides

KW - arterial hypertension

KW - nanocomposites

KW - silicon-organic nanoparticles

KW - RNA

UR - http://www.scopus.com/inward/record.url?scp=85067977924&partnerID=8YFLogxK

U2 - 10.1007/s10517-019-04473-5

DO - 10.1007/s10517-019-04473-5

M3 - Article

C2 - 31177453

AN - SCOPUS:85067977924

VL - 167

SP - 116

EP - 119

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -

ID: 20708577