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Analysis of in vitro cytotoxicity of human nk cell line co-expressing a psma-specific car and an antitumor agent lactaptin. / Belovezhets, T. N.; Matvienko, D. A.; Volkova, O. Y. et al.

In: Genes and Cells, Vol. 13, No. 3, 01.01.2018, p. 89-93.

Research output: Contribution to journal › Article › peer-review

Harvard

Belovezhets, TN, Matvienko, DA, Volkova, OY, Koval, OA, Tkachenko, AV, Kuligina, EV, Taranin, AV & Richter, VA 2018, 'Analysis of in vitro cytotoxicity of human nk cell line co-expressing a psma-specific car and an antitumor agent lactaptin', Genes and Cells, vol. 13, no. 3, pp. 89-93. https://doi.org/10.23868/201811039

APA

Belovezhets, T. N., Matvienko, D. A., Volkova, O. Y., Koval, O. A., Tkachenko, A. V., Kuligina, E. V., Taranin, A. V., & Richter, V. A. (2018). Analysis of in vitro cytotoxicity of human nk cell line co-expressing a psma-specific car and an antitumor agent lactaptin. Genes and Cells, 13(3), 89-93. https://doi.org/10.23868/201811039

Vancouver

Belovezhets TN, Matvienko DA, Volkova OY, Koval OA, Tkachenko AV, Kuligina EV et al. Analysis of in vitro cytotoxicity of human nk cell line co-expressing a psma-specific car and an antitumor agent lactaptin. Genes and Cells. 2018 Jan 1;13(3):89-93. doi: 10.23868/201811039

Author

Belovezhets, T. N. ; Matvienko, D. A. ; Volkova, O. Y. et al. / Analysis of in vitro cytotoxicity of human nk cell line co-expressing a psma-specific car and an antitumor agent lactaptin. In: Genes and Cells. 2018 ; Vol. 13, No. 3. pp. 89-93.

BibTeX

@article{ff9c9ee32c52484287b459b11e44afa2,
title = "Analysis of in vitro cytotoxicity of human nk cell line co-expressing a psma-specific car and an antitumor agent lactaptin",
abstract = "Development of efficient antitumor modalities remains a priority of modern translation medicine. Adoptive transfer of autologous T cells expressing chimeric antigen receptors (CARs) specific for tumor-associated surface targets of B cells has demonstrated encouraging results in recent clinical trials. It is tempting therefore to adapt this approach to solid cancers and move it to universal/allogeneic formats. For this reason, it appears very attractive to use human NK cell lines as CAR carriers. Using lentiviral delivery, human NK cell line YT was modified to express a PSMA-specific CAR and to produce an anticancer peptide lactaptin. “Armored” CAR-YT-Lact cell line obtained shows cytotoxicity against PSMA-positive prostate adenocarcinoma cells. Accordingly, YT-Lact cells display a moderate and non-specific activity against PSMA-negative target cells, which may translate into a tighter control of tumor cell escape via antigen loss.",
keywords = "CAR, Lactaptin, NK cell lines, YT",
author = "Belovezhets, {T. N.} and Matvienko, {D. A.} and Volkova, {O. Y.} and Koval, {O. A.} and Tkachenko, {A. V.} and Kuligina, {E. V.} and Taranin, {A. V.} and Richter, {V. A.}",
note = "Беловежец Т.Н., Матвиенко Д., Волкова О.Ю., Коваль О.А., Ткаченко А.В., Кулигина Е.В., Таранин А.В., Рихтер В. Создание и анализ цитотоксической активности in vitro NK-клеточной линии человека с экспрессией PSMA-специфичного химерного антигенного рецептора и противоопухолевого агента лактаптина // Гены и Клетки. - 2018. - Т. 13. - № 3. - С. 89-93",
year = "2018",
month = jan,
day = "1",
doi = "10.23868/201811039",
language = "English",
volume = "13",
pages = "89--93",
journal = "Genes and Cells",
issn = "2313-1829",
publisher = "Human Stem Cells Institute OJSC (HSCI)",
number = "3",

}

RIS

TY - JOUR

T1 - Analysis of in vitro cytotoxicity of human nk cell line co-expressing a psma-specific car and an antitumor agent lactaptin

AU - Belovezhets, T. N.

AU - Matvienko, D. A.

AU - Volkova, O. Y.

AU - Koval, O. A.

AU - Tkachenko, A. V.

AU - Kuligina, E. V.

AU - Taranin, A. V.

AU - Richter, V. A.

N1 - Беловежец Т.Н., Матвиенко Д., Волкова О.Ю., Коваль О.А., Ткаченко А.В., Кулигина Е.В., Таранин А.В., Рихтер В. Создание и анализ цитотоксической активности in vitro NK-клеточной линии человека с экспрессией PSMA-специфичного химерного антигенного рецептора и противоопухолевого агента лактаптина // Гены и Клетки. - 2018. - Т. 13. - № 3. - С. 89-93

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Development of efficient antitumor modalities remains a priority of modern translation medicine. Adoptive transfer of autologous T cells expressing chimeric antigen receptors (CARs) specific for tumor-associated surface targets of B cells has demonstrated encouraging results in recent clinical trials. It is tempting therefore to adapt this approach to solid cancers and move it to universal/allogeneic formats. For this reason, it appears very attractive to use human NK cell lines as CAR carriers. Using lentiviral delivery, human NK cell line YT was modified to express a PSMA-specific CAR and to produce an anticancer peptide lactaptin. “Armored” CAR-YT-Lact cell line obtained shows cytotoxicity against PSMA-positive prostate adenocarcinoma cells. Accordingly, YT-Lact cells display a moderate and non-specific activity against PSMA-negative target cells, which may translate into a tighter control of tumor cell escape via antigen loss.

AB - Development of efficient antitumor modalities remains a priority of modern translation medicine. Adoptive transfer of autologous T cells expressing chimeric antigen receptors (CARs) specific for tumor-associated surface targets of B cells has demonstrated encouraging results in recent clinical trials. It is tempting therefore to adapt this approach to solid cancers and move it to universal/allogeneic formats. For this reason, it appears very attractive to use human NK cell lines as CAR carriers. Using lentiviral delivery, human NK cell line YT was modified to express a PSMA-specific CAR and to produce an anticancer peptide lactaptin. “Armored” CAR-YT-Lact cell line obtained shows cytotoxicity against PSMA-positive prostate adenocarcinoma cells. Accordingly, YT-Lact cells display a moderate and non-specific activity against PSMA-negative target cells, which may translate into a tighter control of tumor cell escape via antigen loss.

KW - CAR

KW - Lactaptin

KW - NK cell lines

KW - YT

UR - http://www.scopus.com/inward/record.url?scp=85085747080&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=36965272

U2 - 10.23868/201811039

DO - 10.23868/201811039

M3 - Article

AN - SCOPUS:85085747080

VL - 13

SP - 89

EP - 93

JO - Genes and Cells

JF - Genes and Cells

SN - 2313-1829

IS - 3

ER -

ID: 24516553