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Analysis of Behavior and Brain Neuronal Density in B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J Mice, a Parkinson’s Disease Model. / Rozhkova, I. N.; Okotrub, S. V.; Brusentsev, E. Yu. et al.

In: Journal of Evolutionary Biochemistry and Physiology, Vol. 59, No. 5, 10.11.2023, p. 1633-1647.

Research output: Contribution to journal › Article › peer-review

Harvard

Rozhkova, IN, Okotrub, SV, Brusentsev, EY, Rakhmanova, TA, Lebedeva, DA, Kozeneva, VS, Khotskin, NV & Amstislavsky, SY 2023, 'Analysis of Behavior and Brain Neuronal Density in B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J Mice, a Parkinson’s Disease Model', Journal of Evolutionary Biochemistry and Physiology, vol. 59, no. 5, pp. 1633-1647. https://doi.org/10.1134/s0022093023050149

APA

Rozhkova, I. N., Okotrub, S. V., Brusentsev, E. Y., Rakhmanova, T. A., Lebedeva, D. A., Kozeneva, V. S., Khotskin, N. V., & Amstislavsky, S. Y. (2023). Analysis of Behavior and Brain Neuronal Density in B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J Mice, a Parkinson’s Disease Model. Journal of Evolutionary Biochemistry and Physiology, 59(5), 1633-1647. https://doi.org/10.1134/s0022093023050149

Vancouver

Rozhkova IN, Okotrub SV, Brusentsev EY, Rakhmanova TA, Lebedeva DA, Kozeneva VS et al. Analysis of Behavior and Brain Neuronal Density in B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J Mice, a Parkinson’s Disease Model. Journal of Evolutionary Biochemistry and Physiology. 2023 Nov 10;59(5):1633-1647. doi: 10.1134/s0022093023050149

Author

Rozhkova, I. N. ; Okotrub, S. V. ; Brusentsev, E. Yu. et al. / Analysis of Behavior and Brain Neuronal Density in B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J Mice, a Parkinson’s Disease Model. In: Journal of Evolutionary Biochemistry and Physiology. 2023 ; Vol. 59, No. 5. pp. 1633-1647.

BibTeX

@article{e11c8aa2ff55491497514fc82d8aebc9,
title = "Analysis of Behavior and Brain Neuronal Density in B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J Mice, a Parkinson{\textquoteright}s Disease Model",
abstract = "Parkinson's disease (PD) is a progressive age-related neurodegenerative pathology of the central nervous system, characterized by a selective loss of dopaminergic neurons of the nigrostriatal pathway and the presence of specific inclusions (Lewy bodies) in dopaminergic neurons. To study the mechanisms of this pathology and to search for possible ways for its correction, genetic mouse models of PD have been designed. Transgenic mice of the B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J strain (hereinafter referred to as B6.Cg-Tg), one of such models, carry the A53T mutation in the human alpha-synuclein gene. The aim of this work was to study the locomotor activity and the level of anxiety, as well as the density of neurons in the brain of male B6.Cg-Tg mice aged six months. Sex- and age-matched wild type C57BL/6J mice were used as controls. The obtained results demonstrate that B6.Cg-Tg mice are characterized by a high locomotor activity and low anxiety. In addition, they demonstrate a selective decrease in the density of neurons in the subventricular zone and substantia nigra, as well as in the hippocampal CA1, CA3, CA4 regions and the granular layer of the dentate gyrus. Thus, B6.Cg-Tg mice at the age of six months only partially match the key pathophysiological hallmarks of PD, such as a reduced neuronal density in the substantia nigra and hippocampal CA1 and CA3 regions. Meanwhile, these mice have neither bradykinesia nor high levels of anxiety.",
keywords = "MICE, C57BL/6J, B6.CG-TG(PRNP-SNCA*A53T)23MKLE/J, PARKINSON'S DISEASE, LOCOMOTOR ACTIVITY, ANXIETY, BRAIN, NEURONAL DENSITY, EVOLUTIONARY BIOLOGY, BIOCHEMISTRY, GENERAL, ANIMAL PHYSIOLOGY",
author = "Rozhkova, {I. N.} and Okotrub, {S. V.} and Brusentsev, {E. Yu.} and Rakhmanova, {T. A.} and Lebedeva, {D. A.} and Kozeneva, {V. S.} and Khotskin, {N. V.} and Amstislavsky, {S. Ya.}",
note = "Analysis of Behavior and Brain Neuronal Density in B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J Mice, a Parkinson{\textquoteright}s Disease Model / I. N. Rozhkova, S. V. Okotrub, E. Yu. Brusentsev [et al.] // Journal of Evolutionary Biochemistry and Physiology. – 2023. – Vol. 59, No. 5. – P. 1633-1647. – DOI 10.1134/s0022093023050149. This work was supported by the Russian Science Foundation grant No. 23-25-00123 with the use of the equipment of the Center for Genetic Resources of Laboratory Animals at ICG SB RAS (Unique identifier of the project RFMEFI62119X0023) and the Microscopic Center of ICG SB RAS (Novosibirsk, Russia). ",
year = "2023",
month = nov,
day = "10",
doi = "10.1134/s0022093023050149",
language = "English",
volume = "59",
pages = "1633--1647",
journal = "Journal of Evolutionary Biochemistry and Physiology",
issn = "0022-0930",
publisher = "Springer Nature",
number = "5",

}

RIS

TY - JOUR

T1 - Analysis of Behavior and Brain Neuronal Density in B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J Mice, a Parkinson’s Disease Model

AU - Rozhkova, I. N.

AU - Okotrub, S. V.

AU - Brusentsev, E. Yu.

AU - Rakhmanova, T. A.

AU - Lebedeva, D. A.

AU - Kozeneva, V. S.

AU - Khotskin, N. V.

AU - Amstislavsky, S. Ya.

N1 - Analysis of Behavior and Brain Neuronal Density in B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J Mice, a Parkinson’s Disease Model / I. N. Rozhkova, S. V. Okotrub, E. Yu. Brusentsev [et al.] // Journal of Evolutionary Biochemistry and Physiology. – 2023. – Vol. 59, No. 5. – P. 1633-1647. – DOI 10.1134/s0022093023050149. This work was supported by the Russian Science Foundation grant No. 23-25-00123 with the use of the equipment of the Center for Genetic Resources of Laboratory Animals at ICG SB RAS (Unique identifier of the project RFMEFI62119X0023) and the Microscopic Center of ICG SB RAS (Novosibirsk, Russia).

PY - 2023/11/10

Y1 - 2023/11/10

N2 - Parkinson's disease (PD) is a progressive age-related neurodegenerative pathology of the central nervous system, characterized by a selective loss of dopaminergic neurons of the nigrostriatal pathway and the presence of specific inclusions (Lewy bodies) in dopaminergic neurons. To study the mechanisms of this pathology and to search for possible ways for its correction, genetic mouse models of PD have been designed. Transgenic mice of the B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J strain (hereinafter referred to as B6.Cg-Tg), one of such models, carry the A53T mutation in the human alpha-synuclein gene. The aim of this work was to study the locomotor activity and the level of anxiety, as well as the density of neurons in the brain of male B6.Cg-Tg mice aged six months. Sex- and age-matched wild type C57BL/6J mice were used as controls. The obtained results demonstrate that B6.Cg-Tg mice are characterized by a high locomotor activity and low anxiety. In addition, they demonstrate a selective decrease in the density of neurons in the subventricular zone and substantia nigra, as well as in the hippocampal CA1, CA3, CA4 regions and the granular layer of the dentate gyrus. Thus, B6.Cg-Tg mice at the age of six months only partially match the key pathophysiological hallmarks of PD, such as a reduced neuronal density in the substantia nigra and hippocampal CA1 and CA3 regions. Meanwhile, these mice have neither bradykinesia nor high levels of anxiety.

AB - Parkinson's disease (PD) is a progressive age-related neurodegenerative pathology of the central nervous system, characterized by a selective loss of dopaminergic neurons of the nigrostriatal pathway and the presence of specific inclusions (Lewy bodies) in dopaminergic neurons. To study the mechanisms of this pathology and to search for possible ways for its correction, genetic mouse models of PD have been designed. Transgenic mice of the B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J strain (hereinafter referred to as B6.Cg-Tg), one of such models, carry the A53T mutation in the human alpha-synuclein gene. The aim of this work was to study the locomotor activity and the level of anxiety, as well as the density of neurons in the brain of male B6.Cg-Tg mice aged six months. Sex- and age-matched wild type C57BL/6J mice were used as controls. The obtained results demonstrate that B6.Cg-Tg mice are characterized by a high locomotor activity and low anxiety. In addition, they demonstrate a selective decrease in the density of neurons in the subventricular zone and substantia nigra, as well as in the hippocampal CA1, CA3, CA4 regions and the granular layer of the dentate gyrus. Thus, B6.Cg-Tg mice at the age of six months only partially match the key pathophysiological hallmarks of PD, such as a reduced neuronal density in the substantia nigra and hippocampal CA1 and CA3 regions. Meanwhile, these mice have neither bradykinesia nor high levels of anxiety.

KW - MICE

KW - C57BL/6J

KW - B6.CG-TG(PRNP-SNCAA53T)23MKLE/J

KW - PARKINSON'S DISEASE

KW - LOCOMOTOR ACTIVITY

KW - ANXIETY

KW - BRAIN

KW - NEURONAL DENSITY

KW - EVOLUTIONARY BIOLOGY

KW - BIOCHEMISTRY

KW - GENERAL

KW - ANIMAL PHYSIOLOGY

UR - https://www.mendeley.com/catalogue/cca38e5d-70c8-3e45-a048-a198b2880d4a/

UR - https://www.elibrary.ru/item.asp?id=63932113

U2 - 10.1134/s0022093023050149

DO - 10.1134/s0022093023050149

M3 - Article

VL - 59

SP - 1633

EP - 1647

JO - Journal of Evolutionary Biochemistry and Physiology

JF - Journal of Evolutionary Biochemistry and Physiology

SN - 0022-0930

IS - 5

ER -

ID: 68317996