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Analysis of a novel hypomorphic mutation in Trithorax-like gene affecting Drosophila melanogaster oogenesis. / Ogienko, A. A.; Karagodin, D. A.; Fedorova, S. A. et al.

In: Russian Journal of Developmental Biology, Vol. 37, No. 3, 05.2006, p. 173-181.

Research output: Contribution to journal › Article › peer-review

Harvard

Ogienko, AA, Karagodin, DA, Fedorova, SA, Fedorova, EV, Lashina, VV & Baricheva, EM 2006, 'Analysis of a novel hypomorphic mutation in Trithorax-like gene affecting Drosophila melanogaster oogenesis', Russian Journal of Developmental Biology, vol. 37, no. 3, pp. 173-181. https://doi.org/10.1134/S1062360406030052

APA

Ogienko, A. A., Karagodin, D. A., Fedorova, S. A., Fedorova, E. V., Lashina, V. V., & Baricheva, E. M. (2006). Analysis of a novel hypomorphic mutation in Trithorax-like gene affecting Drosophila melanogaster oogenesis. Russian Journal of Developmental Biology, 37(3), 173-181. https://doi.org/10.1134/S1062360406030052

Vancouver

Ogienko AA, Karagodin DA, Fedorova SA, Fedorova EV, Lashina VV, Baricheva EM. Analysis of a novel hypomorphic mutation in Trithorax-like gene affecting Drosophila melanogaster oogenesis. Russian Journal of Developmental Biology. 2006 May;37(3):173-181. doi: 10.1134/S1062360406030052

Author

Ogienko, A. A. ; Karagodin, D. A. ; Fedorova, S. A. et al. / Analysis of a novel hypomorphic mutation in Trithorax-like gene affecting Drosophila melanogaster oogenesis. In: Russian Journal of Developmental Biology. 2006 ; Vol. 37, No. 3. pp. 173-181.

BibTeX

@article{bde2155e97924bd386a55f1596ac7fe4,
title = "Analysis of a novel hypomorphic mutation in Trithorax-like gene affecting Drosophila melanogaster oogenesis",
abstract = "We generated and characterized a new hypomorphic mutation of Drosophila melanogaster Trithorax-like (Trl) gene named Trl362 . The Trl 362 homozygous females are sterile and lay a small number of eggs; most embryos die at the early developmental stages. The transcriptional Trl level of adult Trl362 females was markedly lowered. Little or no GAGA protein, encoded by Trl, was detected in the nurse cell nuclei. The ovaries of Trl362 females showed impairments, such considerable changes in the structure of both ovarioles and individual egg chambers. We believe that the observed ovarian defects in Trl362 mutants are mostly due to a decreased amount of GAGA protein in the germline cells. An increase of GAGA-519 protein caused by introduction of hsp83:GAGA-519 transgene against Trl 362 background rescued partially the female fertility. It may well be that a decrease of GAGA protein in Trl362 germline cells leads to a defective expression of the genes regulated by transcription factor GAGA, whose products are essential for normal Drosphila oogenesis.",
keywords = "Drosophila melanogaster, Oogenesis, Trithorax-like gene",
author = "Ogienko, {A. A.} and Karagodin, {D. A.} and Fedorova, {S. A.} and Fedorova, {E. V.} and Lashina, {V. V.} and Baricheva, {E. M.}",
year = "2006",
month = may,
doi = "10.1134/S1062360406030052",
language = "English",
volume = "37",
pages = "173--181",
journal = "Russian Journal of Developmental Biology",
issn = "1062-3604",
publisher = "Springer Nature",
number = "3",

}

RIS

TY - JOUR

T1 - Analysis of a novel hypomorphic mutation in Trithorax-like gene affecting Drosophila melanogaster oogenesis

AU - Ogienko, A. A.

AU - Karagodin, D. A.

AU - Fedorova, S. A.

AU - Fedorova, E. V.

AU - Lashina, V. V.

AU - Baricheva, E. M.

PY - 2006/5

Y1 - 2006/5

N2 - We generated and characterized a new hypomorphic mutation of Drosophila melanogaster Trithorax-like (Trl) gene named Trl362 . The Trl 362 homozygous females are sterile and lay a small number of eggs; most embryos die at the early developmental stages. The transcriptional Trl level of adult Trl362 females was markedly lowered. Little or no GAGA protein, encoded by Trl, was detected in the nurse cell nuclei. The ovaries of Trl362 females showed impairments, such considerable changes in the structure of both ovarioles and individual egg chambers. We believe that the observed ovarian defects in Trl362 mutants are mostly due to a decreased amount of GAGA protein in the germline cells. An increase of GAGA-519 protein caused by introduction of hsp83:GAGA-519 transgene against Trl 362 background rescued partially the female fertility. It may well be that a decrease of GAGA protein in Trl362 germline cells leads to a defective expression of the genes regulated by transcription factor GAGA, whose products are essential for normal Drosphila oogenesis.

AB - We generated and characterized a new hypomorphic mutation of Drosophila melanogaster Trithorax-like (Trl) gene named Trl362 . The Trl 362 homozygous females are sterile and lay a small number of eggs; most embryos die at the early developmental stages. The transcriptional Trl level of adult Trl362 females was markedly lowered. Little or no GAGA protein, encoded by Trl, was detected in the nurse cell nuclei. The ovaries of Trl362 females showed impairments, such considerable changes in the structure of both ovarioles and individual egg chambers. We believe that the observed ovarian defects in Trl362 mutants are mostly due to a decreased amount of GAGA protein in the germline cells. An increase of GAGA-519 protein caused by introduction of hsp83:GAGA-519 transgene against Trl 362 background rescued partially the female fertility. It may well be that a decrease of GAGA protein in Trl362 germline cells leads to a defective expression of the genes regulated by transcription factor GAGA, whose products are essential for normal Drosphila oogenesis.

KW - Drosophila melanogaster

KW - Oogenesis

KW - Trithorax-like gene

UR - http://www.scopus.com/inward/record.url?scp=33744488015&partnerID=8YFLogxK

U2 - 10.1134/S1062360406030052

DO - 10.1134/S1062360406030052

M3 - Article

AN - SCOPUS:33744488015

VL - 37

SP - 173

EP - 181

JO - Russian Journal of Developmental Biology

JF - Russian Journal of Developmental Biology

SN - 1062-3604

IS - 3

ER -

ID: 25440201