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Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors
Research output
:
Contribution to journal
›
Article
›
peer-review
Organic Chemistry Section
Section of Molecular Biology and Biotechnology
Overview
Cite this
DOI
https://doi.org/10.1016/j.bioorg.2017.12.005
Final published version
Konstantin Yu Ponomarev
Evgeniy V. Suslov
Alexandra L. Zakharenko
Olga D. Zakharova
Artem D. Rogachev
Dina V. Korchagina
Ayesha Zafar
Jóhannes Reynisson
Andrey A. Nefedov
Konstantin P. Volcho
Nariman F. Salakhutdinov
Olga I. Lavrik
Original language
English
Pages (from-to)
392-399
Number of pages
8
Journal
Bioorganic Chemistry
Volume
76
DOIs
https://doi.org/10.1016/j.bioorg.2017.12.005
Publication status
Published -
1 Feb 2018
OECD FOS+WOS
Research areas
Adamantanes, Amine, Chemical space, Cytotoxicity, Fluorescent assay, Natural products, Tdp1, molecular modelling, 2-AMINOADAMANTANE DERIVATIVES, EMPIRICAL SCORING FUNCTIONS, CAMPTOTHECINS, TOPOISOMERASE-I, CANCER, PROTEIN-LIGAND DOCKING, DATA-BANK, BIOLOGICAL EVALUATION, ADAMANTANE DERIVATIVES, TDP1 INHIBITORS, Stereoisomerism, Humans, Monoterpenes/chemical synthesis, Adamantane/analogs & derivatives, Binding Sites, HCT116 Cells, Phosphodiesterase Inhibitors/chemical synthesis, Antineoplastic Agents/chemical synthesis, Amines/chemical synthesis, Drug Synergism, Phosphoric Diester Hydrolases/chemistry, Topotecan/pharmacology, Molecular Docking Simulation, Drug Screening Assays, Antitumor
ID: 9265041
