Standard

Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair. / Shilkin, E. S.; Petrova, D. V.; Zharkov, D. O. et al.

In: Molecular Biology, Vol. 57, No. 4, 08.2023, p. 584-592.

Research output: Contribution to journal › Article › peer-review

Harvard

Shilkin, ES, Petrova, DV, Zharkov, DO & Makarova, AV 2023, 'Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair', Molecular Biology, vol. 57, no. 4, pp. 584-592. https://doi.org/10.1134/S0026893323040155

APA

Shilkin, E. S., Petrova, D. V., Zharkov, D. O., & Makarova, A. V. (2023). Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair. Molecular Biology, 57(4), 584-592. https://doi.org/10.1134/S0026893323040155

Vancouver

Shilkin ES, Petrova DV, Zharkov DO, Makarova AV. Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair. Molecular Biology. 2023 Aug;57(4):584-592. doi: 10.1134/S0026893323040155

Author

Shilkin, E. S. ; Petrova, D. V. ; Zharkov, D. O. et al. / Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair. In: Molecular Biology. 2023 ; Vol. 57, No. 4. pp. 584-592.

BibTeX

@article{1d2977ae6b174852901ee2064185755b,
title = "Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair",
abstract = "5-Methyl-2'-deoxycytidine (mC) at CpG sites plays a key role in the epigenetic gene regulation, cell differentiation, and carcinogenesis. Despite the importance of mC for normal cell function, CpG dinucleotides are known as mutagenesis hotspots. Deamination of mC yields T, causing C→T transitions. However, several recent studies demonstrated the effect of epigenetic modifications of C on the fidelity and efficiency of DNA polymerases and excision repair enzymes. The review summarizes the available data that indicate the existence of deamination-independent mechanisms of mutagenesis at CpG sites.",
keywords = "5-methyl-2'-deoxycytidine, CpG sites, DNA lesions, DNA polymerases, repair",
author = "Shilkin, {E. S.} and Petrova, {D. V.} and Zharkov, {D. O.} and Makarova, {A. V.}",
note = "This work was supported by the Russian Science Foundation (project no. 22-24-20156 (E.S. Shikin)). The analysis of mutagenesis during DNA repair was supported by the Ministry of Science and Higher Education of the Russian Federation (state contract no. 121031300056-8). Публикация для корректировки.",
year = "2023",
month = aug,
doi = "10.1134/S0026893323040155",
language = "English",
volume = "57",
pages = "584--592",
journal = "Molecular Biology",
issn = "0026-8933",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "4",

}

RIS

TY - JOUR

T1 - Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair

AU - Shilkin, E. S.

AU - Petrova, D. V.

AU - Zharkov, D. O.

AU - Makarova, A. V.

N1 - This work was supported by the Russian Science Foundation (project no. 22-24-20156 (E.S. Shikin)). The analysis of mutagenesis during DNA repair was supported by the Ministry of Science and Higher Education of the Russian Federation (state contract no. 121031300056-8). Публикация для корректировки.

PY - 2023/8

Y1 - 2023/8

N2 - 5-Methyl-2'-deoxycytidine (mC) at CpG sites plays a key role in the epigenetic gene regulation, cell differentiation, and carcinogenesis. Despite the importance of mC for normal cell function, CpG dinucleotides are known as mutagenesis hotspots. Deamination of mC yields T, causing C→T transitions. However, several recent studies demonstrated the effect of epigenetic modifications of C on the fidelity and efficiency of DNA polymerases and excision repair enzymes. The review summarizes the available data that indicate the existence of deamination-independent mechanisms of mutagenesis at CpG sites.

AB - 5-Methyl-2'-deoxycytidine (mC) at CpG sites plays a key role in the epigenetic gene regulation, cell differentiation, and carcinogenesis. Despite the importance of mC for normal cell function, CpG dinucleotides are known as mutagenesis hotspots. Deamination of mC yields T, causing C→T transitions. However, several recent studies demonstrated the effect of epigenetic modifications of C on the fidelity and efficiency of DNA polymerases and excision repair enzymes. The review summarizes the available data that indicate the existence of deamination-independent mechanisms of mutagenesis at CpG sites.

KW - 5-methyl-2'-deoxycytidine

KW - CpG sites

KW - DNA lesions

KW - DNA polymerases

KW - repair

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85168264715&origin=inward&txGid=81e2d1a888814384824bd4085590ae49

UR - https://www.mendeley.com/catalogue/4a912a11-06b1-306f-a6b1-c8591d8b2591/

U2 - 10.1134/S0026893323040155

DO - 10.1134/S0026893323040155

M3 - Article

VL - 57

SP - 584

EP - 592

JO - Molecular Biology

JF - Molecular Biology

SN - 0026-8933

IS - 4

ER -

ID: 59556129