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Allele rs2010963 C of the VEGFA gene is associated with the decreased risk of primary varicose veins in ethnic Russians. / Shadrina, Alexandra S.; Smetanina, Mariya A.; Sokolova, Ekaterina A. et al.

In: Phlebology, Vol. 33, No. 1, 01.02.2018, p. 27-35.

Research output: Contribution to journal › Article › peer-review

Harvard

Shadrina, AS, Smetanina, MA, Sokolova, EA, Shamovskaya, DV, Sevost‘ianova, KS, Shevela, AI, Soldatsky, EY, Seliverstov, EI, Demekhova, MY, Shonov, OA, Ilyukhin, EA, Voronina, EN, Pikalov, IV, Zolotukhin, IA, Kirienko, AI & Filipenko, ML 2018, 'Allele rs2010963 C of the VEGFA gene is associated with the decreased risk of primary varicose veins in ethnic Russians', Phlebology, vol. 33, no. 1, pp. 27-35. https://doi.org/10.1177/0268355516683611

APA

Shadrina, A. S., Smetanina, M. A., Sokolova, E. A., Shamovskaya, D. V., Sevost‘ianova, K. S., Shevela, A. I., Soldatsky, E. Y., Seliverstov, E. I., Demekhova, M. Y., Shonov, O. A., Ilyukhin, E. A., Voronina, E. N., Pikalov, I. V., Zolotukhin, I. A., Kirienko, A. I., & Filipenko, M. L. (2018). Allele rs2010963 C of the VEGFA gene is associated with the decreased risk of primary varicose veins in ethnic Russians. Phlebology, 33(1), 27-35. https://doi.org/10.1177/0268355516683611

Vancouver

Shadrina AS, Smetanina MA, Sokolova EA, Shamovskaya DV, Sevost‘ianova KS, Shevela AI et al. Allele rs2010963 C of the VEGFA gene is associated with the decreased risk of primary varicose veins in ethnic Russians. Phlebology. 2018 Feb 1;33(1):27-35. doi: 10.1177/0268355516683611

Author

Shadrina, Alexandra S. ; Smetanina, Mariya A. ; Sokolova, Ekaterina A. et al. / Allele rs2010963 C of the VEGFA gene is associated with the decreased risk of primary varicose veins in ethnic Russians. In: Phlebology. 2018 ; Vol. 33, No. 1. pp. 27-35.

BibTeX

@article{5ae3cc708fa7407fb8e224134f683630,
title = "Allele rs2010963 C of the VEGFA gene is associated with the decreased risk of primary varicose veins in ethnic Russians",
abstract = "Objective: To study the association of polymorphisms rs699947, rs2010963, rs3025039 in the VEGFA gene region and rs1870377, rs2305949, rs2071559 in the VEGFR2 gene region with the risk of primary varicose veins in ethnic Russians. Methods: Genotypes were determined by real-time PCR allelic discrimination. The case group consisted of 448 patients with primary varicose veins and the control group comprised 609 individuals without a history of chronic venous disease. Association was studied by logistic regression analysis. Results: Allele rs2010963 C was associated with the decreased risk of varicose veins (additive model of inheritance: odds ratio = 0.73, 95% confidence interval = 0.59–0.91, P = 0.004). Conclusions: Our results provide evidence that polymorphism rs2010963 located in the 5′ untranslated region of the VEGFA gene can influence genetic susceptibility to primary varicose veins in Russians. Otherwise, it can be in linkage disequilibrium with another functional single nucleotide polymorphism that can alter the level of vascular endothelial growth factor A protein.",
keywords = "association, Russians, single nucleotide polymorphism, Varicose veins, vascular endothelial growth factor",
author = "Shadrina, {Alexandra S.} and Smetanina, {Mariya A.} and Sokolova, {Ekaterina A.} and Shamovskaya, {Darya V.} and Sevost{\textquoteleft}ianova, {Kseniya S.} and Shevela, {Andrey I.} and Soldatsky, {Evgenii Y.} and Seliverstov, {Evgenii I.} and Demekhova, {Marina Y.} and Shonov, {Oleg A.} and Ilyukhin, {Evgeny A.} and Voronina, {Elena N.} and Pikalov, {Ilya V.} and Zolotukhin, {Igor A.} and Kirienko, {Alexander I.} and Filipenko, {Maxim L.}",
year = "2018",
month = feb,
day = "1",
doi = "10.1177/0268355516683611",
language = "English",
volume = "33",
pages = "27--35",
journal = "Phlebology",
issn = "0268-3555",
publisher = "SAGE Publications Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Allele rs2010963 C of the VEGFA gene is associated with the decreased risk of primary varicose veins in ethnic Russians

AU - Shadrina, Alexandra S.

AU - Smetanina, Mariya A.

AU - Sokolova, Ekaterina A.

AU - Shamovskaya, Darya V.

AU - Sevost‘ianova, Kseniya S.

AU - Shevela, Andrey I.

AU - Soldatsky, Evgenii Y.

AU - Seliverstov, Evgenii I.

AU - Demekhova, Marina Y.

AU - Shonov, Oleg A.

AU - Ilyukhin, Evgeny A.

AU - Voronina, Elena N.

AU - Pikalov, Ilya V.

AU - Zolotukhin, Igor A.

AU - Kirienko, Alexander I.

AU - Filipenko, Maxim L.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Objective: To study the association of polymorphisms rs699947, rs2010963, rs3025039 in the VEGFA gene region and rs1870377, rs2305949, rs2071559 in the VEGFR2 gene region with the risk of primary varicose veins in ethnic Russians. Methods: Genotypes were determined by real-time PCR allelic discrimination. The case group consisted of 448 patients with primary varicose veins and the control group comprised 609 individuals without a history of chronic venous disease. Association was studied by logistic regression analysis. Results: Allele rs2010963 C was associated with the decreased risk of varicose veins (additive model of inheritance: odds ratio = 0.73, 95% confidence interval = 0.59–0.91, P = 0.004). Conclusions: Our results provide evidence that polymorphism rs2010963 located in the 5′ untranslated region of the VEGFA gene can influence genetic susceptibility to primary varicose veins in Russians. Otherwise, it can be in linkage disequilibrium with another functional single nucleotide polymorphism that can alter the level of vascular endothelial growth factor A protein.

AB - Objective: To study the association of polymorphisms rs699947, rs2010963, rs3025039 in the VEGFA gene region and rs1870377, rs2305949, rs2071559 in the VEGFR2 gene region with the risk of primary varicose veins in ethnic Russians. Methods: Genotypes were determined by real-time PCR allelic discrimination. The case group consisted of 448 patients with primary varicose veins and the control group comprised 609 individuals without a history of chronic venous disease. Association was studied by logistic regression analysis. Results: Allele rs2010963 C was associated with the decreased risk of varicose veins (additive model of inheritance: odds ratio = 0.73, 95% confidence interval = 0.59–0.91, P = 0.004). Conclusions: Our results provide evidence that polymorphism rs2010963 located in the 5′ untranslated region of the VEGFA gene can influence genetic susceptibility to primary varicose veins in Russians. Otherwise, it can be in linkage disequilibrium with another functional single nucleotide polymorphism that can alter the level of vascular endothelial growth factor A protein.

KW - association

KW - Russians

KW - single nucleotide polymorphism

KW - Varicose veins

KW - vascular endothelial growth factor

UR - http://www.scopus.com/inward/record.url?scp=85039452808&partnerID=8YFLogxK

U2 - 10.1177/0268355516683611

DO - 10.1177/0268355516683611

M3 - Article

C2 - 27932624

AN - SCOPUS:85039452808

VL - 33

SP - 27

EP - 35

JO - Phlebology

JF - Phlebology

SN - 0268-3555

IS - 1

ER -

ID: 9264883