Research output: Contribution to journal › Article › peer-review
Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues. / Yanshole, V. V.; Fomenko, M. V.; Yanshole, L. V. et al.
In: Advances in Gerontology, Vol. 13, No. 1, 3, 03.2023, p. 9-15.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues
AU - Yanshole, V. V.
AU - Fomenko, M. V.
AU - Yanshole, L. V.
AU - Osik, N. A.
AU - Radomskaya, E. Y.
AU - Bulgin, D. V.
AU - Tsentalovich, Y. P.
N1 - This research was funded by the Russian Science Foundation, grant no. 22-23-00021, https://rscf.ru/project/22-23-00021/. We thank the Ministry of Science and Higher Education of the RF for access to NMR equipment. Публикация для корректировки.
PY - 2023/3
Y1 - 2023/3
N2 - The study is aimed at determining age-related changes in ocular tissues of crab-eating macaque (Macaca fascicularis). To this end, we measured the concentrations of a total of 71 major metabolites in aqueous humor, vitreous humor, and lens of two groups of animals, young (4-year-old, n = 6) and aged (21-year-old and 27-year-old, n = 2) macaques. Significant age-related changes were revealed for all three tissues. In the lens, the most significant changes were found for cytoprotective compounds – antioxidants, osmolytes, and molecular ultraviolet (UV) filters: the concentrations of these metabolites in the lenses of aged animals are much lower. The observed changes contribute to increased oxidative stress and predispose the lens to the development of cataracts. The majority of cytoprotective metabolites are synthetized in the lens epithelium. Findings of this work indicate that the observed age-related changes may be caused by the impairment of the lens epithelial cells leading to the increase of oxidative stress in the lens nucleus and developing of age-related cataracts.
AB - The study is aimed at determining age-related changes in ocular tissues of crab-eating macaque (Macaca fascicularis). To this end, we measured the concentrations of a total of 71 major metabolites in aqueous humor, vitreous humor, and lens of two groups of animals, young (4-year-old, n = 6) and aged (21-year-old and 27-year-old, n = 2) macaques. Significant age-related changes were revealed for all three tissues. In the lens, the most significant changes were found for cytoprotective compounds – antioxidants, osmolytes, and molecular ultraviolet (UV) filters: the concentrations of these metabolites in the lenses of aged animals are much lower. The observed changes contribute to increased oxidative stress and predispose the lens to the development of cataracts. The majority of cytoprotective metabolites are synthetized in the lens epithelium. Findings of this work indicate that the observed age-related changes may be caused by the impairment of the lens epithelial cells leading to the increase of oxidative stress in the lens nucleus and developing of age-related cataracts.
KW - age-related changes
KW - aqueous humor
KW - lens
KW - metabolome
KW - non-human primate
KW - vitreous humor
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85185680513&origin=inward&txGid=8d2c5d57b899e747f62b6ca1a376501e
UR - https://www.mendeley.com/catalogue/8a0e69e0-59b5-3890-8e77-06eee50bf317/
U2 - 10.1134/S2079057023600246
DO - 10.1134/S2079057023600246
M3 - Article
VL - 13
SP - 9
EP - 15
JO - Advances in Gerontology
JF - Advances in Gerontology
SN - 2079-0589
IS - 1
M1 - 3
ER -
ID: 59731339