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Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues. / Yanshole, V. V.; Fomenko, M. V.; Yanshole, L. V. et al.

In: Advances in Gerontology, Vol. 13, No. 1, 3, 03.2023, p. 9-15.

Research output: Contribution to journalArticlepeer-review

Harvard

Yanshole, VV, Fomenko, MV, Yanshole, LV, Osik, NA, Radomskaya, EY, Bulgin, DV & Tsentalovich, YP 2023, 'Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues', Advances in Gerontology, vol. 13, no. 1, 3, pp. 9-15. https://doi.org/10.1134/S2079057023600246

APA

Yanshole, V. V., Fomenko, M. V., Yanshole, L. V., Osik, N. A., Radomskaya, E. Y., Bulgin, D. V., & Tsentalovich, Y. P. (2023). Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues. Advances in Gerontology, 13(1), 9-15. [3]. https://doi.org/10.1134/S2079057023600246

Vancouver

Yanshole VV, Fomenko MV, Yanshole LV, Osik NA, Radomskaya EY, Bulgin DV et al. Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues. Advances in Gerontology. 2023 Mar;13(1):9-15. 3. doi: 10.1134/S2079057023600246

Author

Yanshole, V. V. ; Fomenko, M. V. ; Yanshole, L. V. et al. / Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues. In: Advances in Gerontology. 2023 ; Vol. 13, No. 1. pp. 9-15.

BibTeX

@article{665a09aae08f40b08fd9709fefe78829,
title = "Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues",
abstract = "The study is aimed at determining age-related changes in ocular tissues of crab-eating macaque (Macaca fascicularis). To this end, we measured the concentrations of a total of 71 major metabolites in aqueous humor, vitreous humor, and lens of two groups of animals, young (4-year-old, n = 6) and aged (21-year-old and 27-year-old, n = 2) macaques. Significant age-related changes were revealed for all three tissues. In the lens, the most significant changes were found for cytoprotective compounds – antioxidants, osmolytes, and molecular ultraviolet (UV) filters: the concentrations of these metabolites in the lenses of aged animals are much lower. The observed changes contribute to increased oxidative stress and predispose the lens to the development of cataracts. The majority of cytoprotective metabolites are synthetized in the lens epithelium. Findings of this work indicate that the observed age-related changes may be caused by the impairment of the lens epithelial cells leading to the increase of oxidative stress in the lens nucleus and developing of age-related cataracts.",
keywords = "age-related changes, aqueous humor, lens, metabolome, non-human primate, vitreous humor",
author = "Yanshole, {V. V.} and Fomenko, {M. V.} and Yanshole, {L. V.} and Osik, {N. A.} and Radomskaya, {E. Y.} and Bulgin, {D. V.} and Tsentalovich, {Y. P.}",
note = "This research was funded by the Russian Science Foundation, grant no. 22-23-00021, https://rscf.ru/project/22-23-00021/. We thank the Ministry of Science and Higher Education of the RF for access to NMR equipment. Публикация для корректировки.",
year = "2023",
month = mar,
doi = "10.1134/S2079057023600246",
language = "English",
volume = "13",
pages = "9--15",
journal = "Advances in Gerontology",
issn = "2079-0589",
publisher = "Maik Nauka Publishing / Springer SBM",
number = "1",

}

RIS

TY - JOUR

T1 - Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues

AU - Yanshole, V. V.

AU - Fomenko, M. V.

AU - Yanshole, L. V.

AU - Osik, N. A.

AU - Radomskaya, E. Y.

AU - Bulgin, D. V.

AU - Tsentalovich, Y. P.

N1 - This research was funded by the Russian Science Foundation, grant no. 22-23-00021, https://rscf.ru/project/22-23-00021/. We thank the Ministry of Science and Higher Education of the RF for access to NMR equipment. Публикация для корректировки.

PY - 2023/3

Y1 - 2023/3

N2 - The study is aimed at determining age-related changes in ocular tissues of crab-eating macaque (Macaca fascicularis). To this end, we measured the concentrations of a total of 71 major metabolites in aqueous humor, vitreous humor, and lens of two groups of animals, young (4-year-old, n = 6) and aged (21-year-old and 27-year-old, n = 2) macaques. Significant age-related changes were revealed for all three tissues. In the lens, the most significant changes were found for cytoprotective compounds – antioxidants, osmolytes, and molecular ultraviolet (UV) filters: the concentrations of these metabolites in the lenses of aged animals are much lower. The observed changes contribute to increased oxidative stress and predispose the lens to the development of cataracts. The majority of cytoprotective metabolites are synthetized in the lens epithelium. Findings of this work indicate that the observed age-related changes may be caused by the impairment of the lens epithelial cells leading to the increase of oxidative stress in the lens nucleus and developing of age-related cataracts.

AB - The study is aimed at determining age-related changes in ocular tissues of crab-eating macaque (Macaca fascicularis). To this end, we measured the concentrations of a total of 71 major metabolites in aqueous humor, vitreous humor, and lens of two groups of animals, young (4-year-old, n = 6) and aged (21-year-old and 27-year-old, n = 2) macaques. Significant age-related changes were revealed for all three tissues. In the lens, the most significant changes were found for cytoprotective compounds – antioxidants, osmolytes, and molecular ultraviolet (UV) filters: the concentrations of these metabolites in the lenses of aged animals are much lower. The observed changes contribute to increased oxidative stress and predispose the lens to the development of cataracts. The majority of cytoprotective metabolites are synthetized in the lens epithelium. Findings of this work indicate that the observed age-related changes may be caused by the impairment of the lens epithelial cells leading to the increase of oxidative stress in the lens nucleus and developing of age-related cataracts.

KW - age-related changes

KW - aqueous humor

KW - lens

KW - metabolome

KW - non-human primate

KW - vitreous humor

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UR - https://www.mendeley.com/catalogue/8a0e69e0-59b5-3890-8e77-06eee50bf317/

U2 - 10.1134/S2079057023600246

DO - 10.1134/S2079057023600246

M3 - Article

VL - 13

SP - 9

EP - 15

JO - Advances in Gerontology

JF - Advances in Gerontology

SN - 2079-0589

IS - 1

M1 - 3

ER -

ID: 59731339