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Adrenochrome formation during photochemical decomposition of “caged” epinephrine derivatives. / Starodubtseva, Ezhena S.; Karogodina, Tatyana Yu; Panfilov, Mikhail A. et al.

In: Photochemical and Photobiological Sciences, Vol. 23, No. 12, 12.2024, p. 2265–2268.

Research output: Contribution to journal › Article › peer-review

Harvard

Starodubtseva, ES, Karogodina, TY, Panfilov, MA, Sheven, DG, Selyutina, OY, Vorob’ev, AY & Moskalensky, AE 2024, 'Adrenochrome formation during photochemical decomposition of “caged” epinephrine derivatives', Photochemical and Photobiological Sciences, vol. 23, no. 12, pp. 2265–2268. https://doi.org/10.1007/s43630-024-00665-9

APA

Starodubtseva, E. S., Karogodina, T. Y., Panfilov, M. A., Sheven, D. G., Selyutina, O. Y., Vorob’ev, A. Y., & Moskalensky, A. E. (2024). Adrenochrome formation during photochemical decomposition of “caged” epinephrine derivatives. Photochemical and Photobiological Sciences, 23(12), 2265–2268. https://doi.org/10.1007/s43630-024-00665-9

Vancouver

Starodubtseva ES, Karogodina TY, Panfilov MA, Sheven DG, Selyutina OY, Vorob’ev AY et al. Adrenochrome formation during photochemical decomposition of “caged” epinephrine derivatives. Photochemical and Photobiological Sciences. 2024 Dec;23(12):2265–2268. doi: 10.1007/s43630-024-00665-9

Author

Starodubtseva, Ezhena S. ; Karogodina, Tatyana Yu ; Panfilov, Mikhail A. et al. / Adrenochrome formation during photochemical decomposition of “caged” epinephrine derivatives. In: Photochemical and Photobiological Sciences. 2024 ; Vol. 23, No. 12. pp. 2265–2268.

BibTeX

@article{0385b111be654e46bdb57f2d814ce805,
title = "Adrenochrome formation during photochemical decomposition of “caged” epinephrine derivatives",
abstract = "Control of biological activity with light is a fascinating idea. “Caged” compounds, molecules modified with photolabile protecting group, are one of the instruments for this purpose. Adrenergic receptors are essential regulators of neuronal, endocrine, cardiovascular, vegetative, and metabolic functions. These receptors are largely used as pharmacologic targets. Photolabile “caged” analogs of adrenergic receptor agonists has been reported more than 30 years ago. We report that the photolysis of epinephrine analogs, apart from liberation of the epinephrine, is accompanied by a formation of significant amount of adrenochrome, a compound with neuro- and cardiotoxic effect.",
keywords = "Adrenochrome, Caged compounds, Epinephrine, Photopharmacology",
author = "Starodubtseva, {Ezhena S.} and Karogodina, {Tatyana Yu} and Panfilov, {Mikhail A.} and Sheven, {Dmitriy G.} and Selyutina, {Olga Yu} and Vorob{\textquoteright}ev, {Alexey Yu} and Moskalensky, {Alexander E.}",
note = "The study was supported by Russian Science Foundation, grant #23-75-10049.",
year = "2024",
month = dec,
doi = "10.1007/s43630-024-00665-9",
language = "English",
volume = "23",
pages = "2265–2268",
journal = "Photochemical and Photobiological Sciences",
issn = "1474-905X",
publisher = "Royal Society of Chemistry",
number = "12",

}

RIS

TY - JOUR

T1 - Adrenochrome formation during photochemical decomposition of “caged” epinephrine derivatives

AU - Starodubtseva, Ezhena S.

AU - Karogodina, Tatyana Yu

AU - Panfilov, Mikhail A.

AU - Sheven, Dmitriy G.

AU - Selyutina, Olga Yu

AU - Vorob’ev, Alexey Yu

AU - Moskalensky, Alexander E.

N1 - The study was supported by Russian Science Foundation, grant #23-75-10049.

PY - 2024/12

Y1 - 2024/12

N2 - Control of biological activity with light is a fascinating idea. “Caged” compounds, molecules modified with photolabile protecting group, are one of the instruments for this purpose. Adrenergic receptors are essential regulators of neuronal, endocrine, cardiovascular, vegetative, and metabolic functions. These receptors are largely used as pharmacologic targets. Photolabile “caged” analogs of adrenergic receptor agonists has been reported more than 30 years ago. We report that the photolysis of epinephrine analogs, apart from liberation of the epinephrine, is accompanied by a formation of significant amount of adrenochrome, a compound with neuro- and cardiotoxic effect.

AB - Control of biological activity with light is a fascinating idea. “Caged” compounds, molecules modified with photolabile protecting group, are one of the instruments for this purpose. Adrenergic receptors are essential regulators of neuronal, endocrine, cardiovascular, vegetative, and metabolic functions. These receptors are largely used as pharmacologic targets. Photolabile “caged” analogs of adrenergic receptor agonists has been reported more than 30 years ago. We report that the photolysis of epinephrine analogs, apart from liberation of the epinephrine, is accompanied by a formation of significant amount of adrenochrome, a compound with neuro- and cardiotoxic effect.

KW - Adrenochrome

KW - Caged compounds

KW - Epinephrine

KW - Photopharmacology

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85210550495&origin=inward&txGid=dad5bdebfc923285ce239eb310ecbf2c

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001366642400001

UR - https://www.mendeley.com/catalogue/8afc7fc0-1473-3201-af11-f429400520eb/

U2 - 10.1007/s43630-024-00665-9

DO - 10.1007/s43630-024-00665-9

M3 - Article

C2 - 39612097

VL - 23

SP - 2265

EP - 2268

JO - Photochemical and Photobiological Sciences

JF - Photochemical and Photobiological Sciences

SN - 1474-905X

IS - 12

ER -

ID: 61203992