Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review
Accelerator-based boron neutron capture therapy: in vivo experiments. / Каныгин, Владимир Владимирович; Касатова, Анна Исмагиловна; Кичигин, Александр Иванович et al.
19th International Congress on Neutron Capture Therapy Granada, Spain, September 27th - October 1st, 2021. Book of Abstacts. Вена : International Atomic Energy Agency, 2021. p. 152 О14.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review
}
TY - GEN
T1 - Accelerator-based boron neutron capture therapy: in vivo experiments
AU - Каныгин, Владимир Владимирович
AU - Касатова, Анна Исмагиловна
AU - Кичигин, Александр Иванович
AU - Завьялов, Евгений Леонидович
AU - Разумов, Иван Алексеевич
AU - Мухамадияров, Ринат Авхадиевич
AU - Таскаев, Сергей Юрьевич
N1 - Conference code: 19
PY - 2021
Y1 - 2021
N2 - The report is about an assessment of a beam at an accelerator neutron source at Budker Institute of Nuclear Physics and its possible application on glioblastoma tumor. An evaluation of the efficacy of boron neutron capture therapy on heterotopic glioblastoma U87 MG in SCID mice using different boron containing drugs was carried out. Accumulation of 10B in tumor and normal tissues was detected using atomic emission spectrometer ICPE-9820 (Shimadzu, Japan). Tumor growth was significantly slower in all irradiated groups from the 7th day after BNCT compared to untreated control group. The differences between experimental groups became significant from the 50th day after BNCT. Liposomal BSH showed better long-term results compared to BPA and non-liposomal BSH.
AB - The report is about an assessment of a beam at an accelerator neutron source at Budker Institute of Nuclear Physics and its possible application on glioblastoma tumor. An evaluation of the efficacy of boron neutron capture therapy on heterotopic glioblastoma U87 MG in SCID mice using different boron containing drugs was carried out. Accumulation of 10B in tumor and normal tissues was detected using atomic emission spectrometer ICPE-9820 (Shimadzu, Japan). Tumor growth was significantly slower in all irradiated groups from the 7th day after BNCT compared to untreated control group. The differences between experimental groups became significant from the 50th day after BNCT. Liposomal BSH showed better long-term results compared to BPA and non-liposomal BSH.
UR - https://www.elibrary.ru/item.asp?id=48013078&pff=1
M3 - Conference contribution
SP - 152
BT - 19th International Congress on Neutron Capture Therapy Granada, Spain, September 27th - October 1st, 2021. Book of Abstacts
PB - International Atomic Energy Agency
CY - Вена
T2 - 19th International Congress on Neutron Capture Therapy
Y2 - 27 September 2021 through 1 October 2021
ER -
ID: 34969559