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Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders. / Trifonova, Ekaterina A.; Mustafin, Zakhar S.; Lashin, Sergey A. et al.

In: International Journal of Molecular Sciences, Vol. 23, No. 2, 967, 16.01.2022.

Research output: Contribution to journal › Review article › peer-review

Harvard

Trifonova, EA, Mustafin, ZS, Lashin, SA & Kochetov, AV 2022, 'Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders', International Journal of Molecular Sciences, vol. 23, no. 2, 967. https://doi.org/10.3390/ijms23020967

APA

Trifonova, E. A., Mustafin, Z. S., Lashin, S. A., & Kochetov, A. V. (2022). Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders. International Journal of Molecular Sciences, 23(2), [967]. https://doi.org/10.3390/ijms23020967

Vancouver

Trifonova EA, Mustafin ZS, Lashin SA, Kochetov AV. Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders. International Journal of Molecular Sciences. 2022 Jan 16;23(2):967. doi: 10.3390/ijms23020967

Author

Trifonova, Ekaterina A. ; Mustafin, Zakhar S. ; Lashin, Sergey A. et al. / Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders. In: International Journal of Molecular Sciences. 2022 ; Vol. 23, No. 2.

BibTeX

@article{2042601579fe49d087027b6195c99924,
title = "Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders",
abstract = "Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by the early onset of communication and behavioral problems. ASD is highly heritable; however, environmental factors also play a considerable role in this disorder. A significant part of both syndromic and idiopathic autism cases could be attributed to disorders caused by mammalian target of rapamycin (mTOR)-dependent translation deregulation. This narrative review analyzes both bioinformatic and experimental evidence that connects mTOR signaling to the maternal autoantibody-related (MAR) autism spectrum and autoimmune neuropsychiatric disorders simultaneously. In addition, we reconstruct a network presenting the interactions between the mTOR signaling and eight MAR ASD genes coding for ASD-specific maternal autoantibody target proteins. The research discussed in this review demonstrates novel perspectives and validates the need for a subtyping of ASD on the grounds of pathogenic mechanisms. The utter necessity of designing ELISA-based test panels to identify all antibodies related to autism-like behavior is also considered.",
keywords = "Autism spectrum disorder (ASD), Autoimmune disorders (AIDs), Bioinformatics, Genetics, Maternal autoantibody-related (MAR) ASD, Maternal immune activation (MIA), MTOR signaling pathway, Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS)",
author = "Trifonova, {Ekaterina A.} and Mustafin, {Zakhar S.} and Lashin, {Sergey A.} and Kochetov, {Alex V.}",
note = "Funding Information: Funding: This research was supported by the Russian State Budgetary Projects FWNR-2022-0006 and FWNR-2022-0020. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = jan,
day = "16",
doi = "10.3390/ijms23020967",
language = "English",
volume = "23",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

RIS

TY - JOUR

T1 - Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders

AU - Trifonova, Ekaterina A.

AU - Mustafin, Zakhar S.

AU - Lashin, Sergey A.

AU - Kochetov, Alex V.

N1 - Funding Information: Funding: This research was supported by the Russian State Budgetary Projects FWNR-2022-0006 and FWNR-2022-0020. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/1/16

Y1 - 2022/1/16

N2 - Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by the early onset of communication and behavioral problems. ASD is highly heritable; however, environmental factors also play a considerable role in this disorder. A significant part of both syndromic and idiopathic autism cases could be attributed to disorders caused by mammalian target of rapamycin (mTOR)-dependent translation deregulation. This narrative review analyzes both bioinformatic and experimental evidence that connects mTOR signaling to the maternal autoantibody-related (MAR) autism spectrum and autoimmune neuropsychiatric disorders simultaneously. In addition, we reconstruct a network presenting the interactions between the mTOR signaling and eight MAR ASD genes coding for ASD-specific maternal autoantibody target proteins. The research discussed in this review demonstrates novel perspectives and validates the need for a subtyping of ASD on the grounds of pathogenic mechanisms. The utter necessity of designing ELISA-based test panels to identify all antibodies related to autism-like behavior is also considered.

AB - Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by the early onset of communication and behavioral problems. ASD is highly heritable; however, environmental factors also play a considerable role in this disorder. A significant part of both syndromic and idiopathic autism cases could be attributed to disorders caused by mammalian target of rapamycin (mTOR)-dependent translation deregulation. This narrative review analyzes both bioinformatic and experimental evidence that connects mTOR signaling to the maternal autoantibody-related (MAR) autism spectrum and autoimmune neuropsychiatric disorders simultaneously. In addition, we reconstruct a network presenting the interactions between the mTOR signaling and eight MAR ASD genes coding for ASD-specific maternal autoantibody target proteins. The research discussed in this review demonstrates novel perspectives and validates the need for a subtyping of ASD on the grounds of pathogenic mechanisms. The utter necessity of designing ELISA-based test panels to identify all antibodies related to autism-like behavior is also considered.

KW - Autism spectrum disorder (ASD)

KW - Autoimmune disorders (AIDs)

KW - Bioinformatics

KW - Genetics

KW - Maternal autoantibody-related (MAR) ASD

KW - Maternal immune activation (MIA)

KW - MTOR signaling pathway

KW - Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS)

UR - http://www.scopus.com/inward/record.url?scp=85122836985&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/348a36e2-03c9-3fd6-8096-e7fabbcc3989/

U2 - 10.3390/ijms23020967

DO - 10.3390/ijms23020967

M3 - Review article

C2 - 35055151

AN - SCOPUS:85122836985

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 2

M1 - 967

ER -

ID: 35263299