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A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors. / Sherstyuk, Yuliya V.; Zakharenko, Alexandra L.; Kutuzov, Mikhail M. et al.

In: Molecular Diversity, Vol. 21, No. 1, 01.02.2017, p. 101-113.

Research output: Contribution to journal › Article › peer-review

Harvard

Sherstyuk, YV, Zakharenko, AL, Kutuzov, MM, Chalova, PV, Sukhanova, MV, Lavrik, OI, Silnikov, VN & Abramova, TV 2017, 'A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors', Molecular Diversity, vol. 21, no. 1, pp. 101-113. https://doi.org/10.1007/s11030-016-9703-x

APA

Sherstyuk, Y. V., Zakharenko, A. L., Kutuzov, M. M., Chalova, P. V., Sukhanova, M. V., Lavrik, O. I., Silnikov, V. N., & Abramova, T. V. (2017). A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors. Molecular Diversity, 21(1), 101-113. https://doi.org/10.1007/s11030-016-9703-x

Vancouver

Sherstyuk YV, Zakharenko AL, Kutuzov MM, Chalova PV, Sukhanova MV, Lavrik OI et al. A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors. Molecular Diversity. 2017 Feb 1;21(1):101-113. doi: 10.1007/s11030-016-9703-x

Author

Sherstyuk, Yuliya V. ; Zakharenko, Alexandra L. ; Kutuzov, Mikhail M. et al. / A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors. In: Molecular Diversity. 2017 ; Vol. 21, No. 1. pp. 101-113.

BibTeX

@article{d922dfc0390a46318b4cbe43b0c99512,
title = "A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors",
abstract = "Abstract: A versatile strategy for the synthesis of NAD + mimetics was developed, involving an efficient pyrophosphate linkage formation in key conjugates containing a functional amino group which acts as useful reactive anchor for further derivatization. These NAD + mimetics consist of ADP conjugated through a diphosphate chain to an extended aliphatic linker bearing an aromatic acid residue. A number of conjugates containing aromatic carboxylic acids were found to inhibit poly(ADP-ribose) synthesis catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1). A new class of potential PARP-1 inhibitors mimicking NAD +, a substrate in the PARP-1 catalyzed reaction, was proposed.",
keywords = "NAD analogues, PARP inhibitors, PARP-1, Pyrophosphate synthesis, NAD/chemistry, Poly (ADP-Ribose) Polymerase-1/antagonists & inhibitors, Chemistry Techniques, Synthetic, Biomimetic Materials/chemical synthesis, Drug Design, Adenosine Diphosphate/chemistry, Enzyme Inhibitors/chemical synthesis, ACID, CHROMATIN, NICOTINAMIDE, PROBING BINDING REQUIREMENTS, STRUCTURAL-ANALYSIS, FUNCTIONALIZATION, REPAIR, DNA, NAD ANALOGS, NAD(+) analogues, PARP INHIBITORS",
author = "Sherstyuk, {Yuliya V.} and Zakharenko, {Alexandra L.} and Kutuzov, {Mikhail M.} and Chalova, {Polina V.} and Sukhanova, {Maria V.} and Lavrik, {Olga I.} and Silnikov, {Vladimir N.} and Abramova, {Tatyana V.}",
note = "Publisher Copyright: {\textcopyright} 2016, Springer International Publishing Switzerland.",
year = "2017",
month = feb,
day = "1",
doi = "10.1007/s11030-016-9703-x",
language = "English",
volume = "21",
pages = "101--113",
journal = "Molecular Diversity",
issn = "1381-1991",
publisher = "Springer Netherlands",
number = "1",

}

RIS

TY - JOUR

T1 - A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors

AU - Sherstyuk, Yuliya V.

AU - Zakharenko, Alexandra L.

AU - Kutuzov, Mikhail M.

AU - Chalova, Polina V.

AU - Sukhanova, Maria V.

AU - Lavrik, Olga I.

AU - Silnikov, Vladimir N.

AU - Abramova, Tatyana V.

N1 - Publisher Copyright: © 2016, Springer International Publishing Switzerland.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Abstract: A versatile strategy for the synthesis of NAD + mimetics was developed, involving an efficient pyrophosphate linkage formation in key conjugates containing a functional amino group which acts as useful reactive anchor for further derivatization. These NAD + mimetics consist of ADP conjugated through a diphosphate chain to an extended aliphatic linker bearing an aromatic acid residue. A number of conjugates containing aromatic carboxylic acids were found to inhibit poly(ADP-ribose) synthesis catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1). A new class of potential PARP-1 inhibitors mimicking NAD +, a substrate in the PARP-1 catalyzed reaction, was proposed.

AB - Abstract: A versatile strategy for the synthesis of NAD + mimetics was developed, involving an efficient pyrophosphate linkage formation in key conjugates containing a functional amino group which acts as useful reactive anchor for further derivatization. These NAD + mimetics consist of ADP conjugated through a diphosphate chain to an extended aliphatic linker bearing an aromatic acid residue. A number of conjugates containing aromatic carboxylic acids were found to inhibit poly(ADP-ribose) synthesis catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1). A new class of potential PARP-1 inhibitors mimicking NAD +, a substrate in the PARP-1 catalyzed reaction, was proposed.

KW - NAD analogues

KW - PARP inhibitors

KW - PARP-1

KW - Pyrophosphate synthesis

KW - NAD/chemistry

KW - Poly (ADP-Ribose) Polymerase-1/antagonists & inhibitors

KW - Chemistry Techniques, Synthetic

KW - Biomimetic Materials/chemical synthesis

KW - Drug Design

KW - Adenosine Diphosphate/chemistry

KW - Enzyme Inhibitors/chemical synthesis

KW - ACID

KW - CHROMATIN

KW - NICOTINAMIDE

KW - PROBING BINDING REQUIREMENTS

KW - STRUCTURAL-ANALYSIS

KW - FUNCTIONALIZATION

KW - REPAIR

KW - DNA

KW - NAD ANALOGS

KW - NAD(+) analogues

KW - PARP INHIBITORS

UR - http://www.scopus.com/inward/record.url?scp=84988723483&partnerID=8YFLogxK

U2 - 10.1007/s11030-016-9703-x

DO - 10.1007/s11030-016-9703-x

M3 - Article

C2 - 27677737

AN - SCOPUS:84988723483

VL - 21

SP - 101

EP - 113

JO - Molecular Diversity

JF - Molecular Diversity

SN - 1381-1991

IS - 1

ER -

ID: 8680829