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A sePARate phase? Poly(ADP-ribose) versus RNA in the organization of biomolecular condensates. / Alemasova, Elizaveta E.; Lavrik, Olga I.

In: Nucleic Acids Research, Vol. 50, No. 19, 28.10.2022, p. 10817-10838.

Research output: Contribution to journal › Review article › peer-review

Harvard

Alemasova, EE & Lavrik, OI 2022, 'A sePARate phase? Poly(ADP-ribose) versus RNA in the organization of biomolecular condensates', Nucleic Acids Research, vol. 50, no. 19, pp. 10817-10838. https://doi.org/10.1093/nar/gkac866

APA

Alemasova, E. E., & Lavrik, O. I. (2022). A sePARate phase? Poly(ADP-ribose) versus RNA in the organization of biomolecular condensates. Nucleic Acids Research, 50(19), 10817-10838. https://doi.org/10.1093/nar/gkac866

Vancouver

Alemasova EE, Lavrik OI. A sePARate phase? Poly(ADP-ribose) versus RNA in the organization of biomolecular condensates. Nucleic Acids Research. 2022 Oct 28;50(19):10817-10838. doi: 10.1093/nar/gkac866

Author

Alemasova, Elizaveta E. ; Lavrik, Olga I. / A sePARate phase? Poly(ADP-ribose) versus RNA in the organization of biomolecular condensates. In: Nucleic Acids Research. 2022 ; Vol. 50, No. 19. pp. 10817-10838.

BibTeX

@article{505c31d86dee42618bfa4c26f4b6b6c9,
title = "A sePARate phase? Poly(ADP-ribose) versus RNA in the organization of biomolecular condensates",
abstract = "Condensates are biomolecular assemblies that concentrate biomolecules without the help of membranes. They are morphologically highly versatile and may emerge via distinct mechanisms. Nucleic acids-DNA, RNA and poly(ADP-ribose) (PAR) play special roles in the process of condensate organization. These polymeric scaffolds provide multiple specific and nonspecific interactions during nucleation and 'development' of macromolecular assemblages. In this review, we focus on condensates formed with PAR. We discuss to what extent the literature supports the phase separation origin of these structures. Special attention is paid to similarities and differences between PAR and RNA in the process of dynamic restructuring of condensates during their functioning.",
keywords = "Poly Adenosine Diphosphate Ribose, RNA/genetics, Biomolecular Condensates, Macromolecular Substances, Nucleic Acids",
author = "Alemasova, {Elizaveta E.} and Lavrik, {Olga I.}",
note = "FUNDING: Russian Science Foundation [20-14-00086, 21-64-00017]. Funding for open access charge: Russian Science Foundation [20-14-00086, 21-64-00017]. Publisher Copyright: {\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.",
year = "2022",
month = oct,
day = "28",
doi = "10.1093/nar/gkac866",
language = "English",
volume = "50",
pages = "10817--10838",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "19",

}

RIS

TY - JOUR

T1 - A sePARate phase? Poly(ADP-ribose) versus RNA in the organization of biomolecular condensates

AU - Alemasova, Elizaveta E.

AU - Lavrik, Olga I.

N1 - FUNDING: Russian Science Foundation [20-14-00086, 21-64-00017]. Funding for open access charge: Russian Science Foundation [20-14-00086, 21-64-00017]. Publisher Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

PY - 2022/10/28

Y1 - 2022/10/28

N2 - Condensates are biomolecular assemblies that concentrate biomolecules without the help of membranes. They are morphologically highly versatile and may emerge via distinct mechanisms. Nucleic acids-DNA, RNA and poly(ADP-ribose) (PAR) play special roles in the process of condensate organization. These polymeric scaffolds provide multiple specific and nonspecific interactions during nucleation and 'development' of macromolecular assemblages. In this review, we focus on condensates formed with PAR. We discuss to what extent the literature supports the phase separation origin of these structures. Special attention is paid to similarities and differences between PAR and RNA in the process of dynamic restructuring of condensates during their functioning.

AB - Condensates are biomolecular assemblies that concentrate biomolecules without the help of membranes. They are morphologically highly versatile and may emerge via distinct mechanisms. Nucleic acids-DNA, RNA and poly(ADP-ribose) (PAR) play special roles in the process of condensate organization. These polymeric scaffolds provide multiple specific and nonspecific interactions during nucleation and 'development' of macromolecular assemblages. In this review, we focus on condensates formed with PAR. We discuss to what extent the literature supports the phase separation origin of these structures. Special attention is paid to similarities and differences between PAR and RNA in the process of dynamic restructuring of condensates during their functioning.

KW - Poly Adenosine Diphosphate Ribose

KW - RNA/genetics

KW - Biomolecular Condensates

KW - Macromolecular Substances

KW - Nucleic Acids

UR - http://www.scopus.com/inward/record.url?scp=85141890641&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/595ad01f-436f-33a4-9138-c5ef36ff5c6e/

U2 - 10.1093/nar/gkac866

DO - 10.1093/nar/gkac866

M3 - Review article

C2 - 36243979

AN - SCOPUS:85141890641

VL - 50

SP - 10817

EP - 10838

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 19

ER -

ID: 39468117