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A New DNA Break Repair Pathway Involving PARP3 and Base Excision Repair Proteins. / Belousova, E. A.; Kutuzov, M. M.; Ivankina, P. A. et al.

In: Doklady Biochemistry and Biophysics, Vol. 482, No. 1, 01.09.2018, p. 233-237.

Research output: Contribution to journal › Article › peer-review

Harvard

Belousova, EA, Kutuzov, MM, Ivankina, PA, Ishchenko, AA & Lavrik, OI 2018, 'A New DNA Break Repair Pathway Involving PARP3 and Base Excision Repair Proteins', Doklady Biochemistry and Biophysics, vol. 482, no. 1, pp. 233-237. https://doi.org/10.1134/S1607672918050010

APA

Belousova, E. A., Kutuzov, M. M., Ivankina, P. A., Ishchenko, A. A., & Lavrik, O. I. (2018). A New DNA Break Repair Pathway Involving PARP3 and Base Excision Repair Proteins. Doklady Biochemistry and Biophysics, 482(1), 233-237. https://doi.org/10.1134/S1607672918050010

Vancouver

Belousova EA, Kutuzov MM, Ivankina PA, Ishchenko AA, Lavrik OI. A New DNA Break Repair Pathway Involving PARP3 and Base Excision Repair Proteins. Doklady Biochemistry and Biophysics. 2018 Sept 1;482(1):233-237. doi: 10.1134/S1607672918050010

Author

Belousova, E. A. ; Kutuzov, M. M. ; Ivankina, P. A. et al. / A New DNA Break Repair Pathway Involving PARP3 and Base Excision Repair Proteins. In: Doklady Biochemistry and Biophysics. 2018 ; Vol. 482, No. 1. pp. 233-237.

BibTeX

@article{3797034dd67f476f8faef9cfcf77b2f4,
title = "A New DNA Break Repair Pathway Involving PARP3 and Base Excision Repair Proteins",
abstract = "Poly(ADP-ribosyl)ation, which is catalyzed by PARP family proteins, is one of the main reactions in the cell response to genomic DNA damage. Massive impact of DNA-damaging agents (such as oxidative stress and ionizing radiation) causes numerous breaks in DNA. In this case, the development of a fast cell response, which allows the genomic DNA integrity to be retained, may be more important than the repair by more accurate but long-term restoration of the DNA structure. This is the first study to show the possibility of eliminating DNA breaks through their PARP3-dependent mono(ADP-ribosyl)ation followed by ligation and repair of the formed ribo-AP sites by the base excision repair (BER) enzyme complex. Taken together, the results of the studies on ADP-ribosylation of DNA and the data obtained in this study suggest that PARP3 may be a component of the DNA break repair system involving the BER enzyme complex.",
author = "Belousova, {E. A.} and Kutuzov, {M. M.} and Ivankina, {P. A.} and Ishchenko, {A. A.} and Lavrik, {O. I.}",
note = "Publisher Copyright: {\textcopyright} 2018, Pleiades Publishing, Ltd.",
year = "2018",
month = sep,
day = "1",
doi = "10.1134/S1607672918050010",
language = "English",
volume = "482",
pages = "233--237",
journal = "Doklady Biochemistry and Biophysics",
issn = "1607-6729",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "1",

}

RIS

TY - JOUR

T1 - A New DNA Break Repair Pathway Involving PARP3 and Base Excision Repair Proteins

AU - Belousova, E. A.

AU - Kutuzov, M. M.

AU - Ivankina, P. A.

AU - Ishchenko, A. A.

AU - Lavrik, O. I.

N1 - Publisher Copyright: © 2018, Pleiades Publishing, Ltd.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Poly(ADP-ribosyl)ation, which is catalyzed by PARP family proteins, is one of the main reactions in the cell response to genomic DNA damage. Massive impact of DNA-damaging agents (such as oxidative stress and ionizing radiation) causes numerous breaks in DNA. In this case, the development of a fast cell response, which allows the genomic DNA integrity to be retained, may be more important than the repair by more accurate but long-term restoration of the DNA structure. This is the first study to show the possibility of eliminating DNA breaks through their PARP3-dependent mono(ADP-ribosyl)ation followed by ligation and repair of the formed ribo-AP sites by the base excision repair (BER) enzyme complex. Taken together, the results of the studies on ADP-ribosylation of DNA and the data obtained in this study suggest that PARP3 may be a component of the DNA break repair system involving the BER enzyme complex.

AB - Poly(ADP-ribosyl)ation, which is catalyzed by PARP family proteins, is one of the main reactions in the cell response to genomic DNA damage. Massive impact of DNA-damaging agents (such as oxidative stress and ionizing radiation) causes numerous breaks in DNA. In this case, the development of a fast cell response, which allows the genomic DNA integrity to be retained, may be more important than the repair by more accurate but long-term restoration of the DNA structure. This is the first study to show the possibility of eliminating DNA breaks through their PARP3-dependent mono(ADP-ribosyl)ation followed by ligation and repair of the formed ribo-AP sites by the base excision repair (BER) enzyme complex. Taken together, the results of the studies on ADP-ribosylation of DNA and the data obtained in this study suggest that PARP3 may be a component of the DNA break repair system involving the BER enzyme complex.

UR - http://www.scopus.com/inward/record.url?scp=85056225641&partnerID=8YFLogxK

U2 - 10.1134/S1607672918050010

DO - 10.1134/S1607672918050010

M3 - Article

C2 - 30397881

AN - SCOPUS:85056225641

VL - 482

SP - 233

EP - 237

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

ER -

ID: 17409428