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A New Bias Site for Epigenetic Modifications : How Non-Canonical GC Base Pairs Favor Mechanochemical Cleavage of DNA. / Semyonov, Denis A.; Eltsov, Ilia V.; Nechipurenko, Yury D.

In: BioEssays, Vol. 42, No. 11, 2000051, 01.11.2020.

Research output: Contribution to journal › Article › peer-review

Harvard

Semyonov, DA, Eltsov, IV & Nechipurenko, YD 2020, 'A New Bias Site for Epigenetic Modifications: How Non-Canonical GC Base Pairs Favor Mechanochemical Cleavage of DNA', BioEssays, vol. 42, no. 11, 2000051. https://doi.org/10.1002/bies.202000051

APA

Semyonov, D. A., Eltsov, I. V., & Nechipurenko, Y. D. (2020). A New Bias Site for Epigenetic Modifications: How Non-Canonical GC Base Pairs Favor Mechanochemical Cleavage of DNA. BioEssays, 42(11), [2000051]. https://doi.org/10.1002/bies.202000051

Vancouver

Semyonov DA, Eltsov IV, Nechipurenko YD. A New Bias Site for Epigenetic Modifications: How Non-Canonical GC Base Pairs Favor Mechanochemical Cleavage of DNA. BioEssays. 2020 Nov 1;42(11):2000051. doi: 10.1002/bies.202000051

Author

Semyonov, Denis A. ; Eltsov, Ilia V. ; Nechipurenko, Yury D. / A New Bias Site for Epigenetic Modifications : How Non-Canonical GC Base Pairs Favor Mechanochemical Cleavage of DNA. In: BioEssays. 2020 ; Vol. 42, No. 11.

BibTeX

@article{2c647dd0a2b64fe0919874f4bf3615f4,
title = "A New Bias Site for Epigenetic Modifications: How Non-Canonical GC Base Pairs Favor Mechanochemical Cleavage of DNA",
abstract = "Properties of non-canonical GC base pairs and their relations with mechanochemical cleavage of DNA are analyzed. A hypothesis of the involvement of the transient GC wobble base pairs both in the mechanisms of the mechanochemical cleavage of DNA and epigenetic mechanisms involving of 5-methylcytosine, is proposed. The hypothesis explains the increase in the frequency of the breaks of the sugar-phosphate backbone of DNA after cytosines, the asymmetric character of these breaks, and an increase in break frequency in CpG after cytosine methylation. As an alternative hypothesis, probable implication of GC+ Hoogsteen base pairs is considered, which now exemplify the best-studied non-canonical GC base pairs in the DNA double helix. Also see the video abstract here https://youtu.be/EUunVWL0ptw.",
keywords = "5-methylcytosines, mechanochemical cleavage of DNAs, molecular basis of epigenetics, tautomers, transient base pairs in DNAs, wobble base pairs, MUTAGENESIS, DEAMINATION, 5-METHYLCYTOSINE, CYTOSINE, NUCLEIC-ACIDS, N-4-METHOXYCYTOSINE, EQUILIBRIUM, TAUTOMERS, 5-FORMYLCYTOSINE, INSIGHTS",
author = "Semyonov, {Denis A.} and Eltsov, {Ilia V.} and Nechipurenko, {Yury D.}",
note = "{\textcopyright} 2020 Wiley Periodicals LLC.",
year = "2020",
month = nov,
day = "1",
doi = "10.1002/bies.202000051",
language = "English",
volume = "42",
journal = "BioEssays",
issn = "0265-9247",
publisher = "John Wiley & Sons Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - A New Bias Site for Epigenetic Modifications

T2 - How Non-Canonical GC Base Pairs Favor Mechanochemical Cleavage of DNA

AU - Semyonov, Denis A.

AU - Eltsov, Ilia V.

AU - Nechipurenko, Yury D.

N1 - © 2020 Wiley Periodicals LLC.

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Properties of non-canonical GC base pairs and their relations with mechanochemical cleavage of DNA are analyzed. A hypothesis of the involvement of the transient GC wobble base pairs both in the mechanisms of the mechanochemical cleavage of DNA and epigenetic mechanisms involving of 5-methylcytosine, is proposed. The hypothesis explains the increase in the frequency of the breaks of the sugar-phosphate backbone of DNA after cytosines, the asymmetric character of these breaks, and an increase in break frequency in CpG after cytosine methylation. As an alternative hypothesis, probable implication of GC+ Hoogsteen base pairs is considered, which now exemplify the best-studied non-canonical GC base pairs in the DNA double helix. Also see the video abstract here https://youtu.be/EUunVWL0ptw.

AB - Properties of non-canonical GC base pairs and their relations with mechanochemical cleavage of DNA are analyzed. A hypothesis of the involvement of the transient GC wobble base pairs both in the mechanisms of the mechanochemical cleavage of DNA and epigenetic mechanisms involving of 5-methylcytosine, is proposed. The hypothesis explains the increase in the frequency of the breaks of the sugar-phosphate backbone of DNA after cytosines, the asymmetric character of these breaks, and an increase in break frequency in CpG after cytosine methylation. As an alternative hypothesis, probable implication of GC+ Hoogsteen base pairs is considered, which now exemplify the best-studied non-canonical GC base pairs in the DNA double helix. Also see the video abstract here https://youtu.be/EUunVWL0ptw.

KW - 5-methylcytosines

KW - mechanochemical cleavage of DNAs

KW - molecular basis of epigenetics

KW - tautomers

KW - transient base pairs in DNAs

KW - wobble base pairs

KW - MUTAGENESIS

KW - DEAMINATION

KW - 5-METHYLCYTOSINE

KW - CYTOSINE

KW - NUCLEIC-ACIDS

KW - N-4-METHOXYCYTOSINE

KW - EQUILIBRIUM

KW - TAUTOMERS

KW - 5-FORMYLCYTOSINE

KW - INSIGHTS

UR - http://www.scopus.com/inward/record.url?scp=85089661659&partnerID=8YFLogxK

U2 - 10.1002/bies.202000051

DO - 10.1002/bies.202000051

M3 - Article

C2 - 32830350

AN - SCOPUS:85089661659

VL - 42

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 11

M1 - 2000051

ER -

ID: 25291000