Research output: Contribution to journal › Article › peer-review
A grounded electrode beneath dielectric targets, including cancer cells, enhances the impact of cold atmospheric plasma jet. / Schweigert, Irina; Zakrevsky, Dmitry; Milakhina, Elena et al.
In: Plasma Physics and Controlled Fusion, Vol. 64, No. 4, 044015, 04.2022.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - A grounded electrode beneath dielectric targets, including cancer cells, enhances the impact of cold atmospheric plasma jet
AU - Schweigert, Irina
AU - Zakrevsky, Dmitry
AU - Milakhina, Elena
AU - Gugin, Pavel
AU - Biryukov, Mikhail
AU - Patrakova, Ekaterina
AU - Koval, Olga
N1 - Funding Information: This research was funded by Russian Science Foundation Grant No. 22-49-08003. Publisher Copyright: © 2022 IOP Publishing Ltd.
PY - 2022/4
Y1 - 2022/4
N2 - The effect of the presence or absence of a grounded substrate beneath dielectric targets, including cancer cells, during exposure to the cold atmospheric plasma jet is studied in the experiments and in fluid model simulations for the discharge parameters typical for the medical applications. It is shown that the dynamics of streamers generated in each positive cycle of ac voltage depends on the grounded substrate position. The streamers approach the target more often if the grounded substrate is beneath the target, that provides more intensive plasma-target interaction. In this case, the measured spectrum of plasma jet emission near the target demonstrates much higher intensity compared to an electrically isolated target case. The calculated and measured discharge currents with time demonstrate a mismatch of frequencies of the ac voltage and current over the target. The viability of A431 human skin carcinoma and MX7 mouse rhabdomyosarcoma cells treated by cold atmospheric plasma jet with/without the grounded substrate is measured with MTT assay 24 h after. The results show an enhanced suppression of the cell viability when using the grounded substrate for both cell lines. Achieving effective death of tumor cells with a shorter irradiation time can be considered an advantage of using a grounded electrode beneath the bio target.
AB - The effect of the presence or absence of a grounded substrate beneath dielectric targets, including cancer cells, during exposure to the cold atmospheric plasma jet is studied in the experiments and in fluid model simulations for the discharge parameters typical for the medical applications. It is shown that the dynamics of streamers generated in each positive cycle of ac voltage depends on the grounded substrate position. The streamers approach the target more often if the grounded substrate is beneath the target, that provides more intensive plasma-target interaction. In this case, the measured spectrum of plasma jet emission near the target demonstrates much higher intensity compared to an electrically isolated target case. The calculated and measured discharge currents with time demonstrate a mismatch of frequencies of the ac voltage and current over the target. The viability of A431 human skin carcinoma and MX7 mouse rhabdomyosarcoma cells treated by cold atmospheric plasma jet with/without the grounded substrate is measured with MTT assay 24 h after. The results show an enhanced suppression of the cell viability when using the grounded substrate for both cell lines. Achieving effective death of tumor cells with a shorter irradiation time can be considered an advantage of using a grounded electrode beneath the bio target.
KW - cancer treatment
KW - cold atmospheric plasma jet
KW - grounded electrode
KW - optimal discharge mode
UR - http://www.scopus.com/inward/record.url?scp=85126665468&partnerID=8YFLogxK
U2 - 10.1088/1361-6587/ac53f1
DO - 10.1088/1361-6587/ac53f1
M3 - Article
AN - SCOPUS:85126665468
VL - 64
JO - Plasma Physics and Controlled Fusion
JF - Plasma Physics and Controlled Fusion
SN - 0741-3335
IS - 4
M1 - 044015
ER -
ID: 35768775