A fatal case of tick-borne rickettsiosis caused by mixed Rickettsia sibirica subsp. sibirica and “Candidatus Rickettsia tarasevichiae” infection in Russia. / Rudakov, Nikolay; Samoylenko, I.; Shtrek, Sergey et al.
In: Ticks and Tick-borne Diseases, Vol. 10, No. 6, 101278, 10.2019.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - A fatal case of tick-borne rickettsiosis caused by mixed Rickettsia sibirica subsp. sibirica and “Candidatus Rickettsia tarasevichiae” infection in Russia
AU - Rudakov, Nikolay
AU - Samoylenko, I.
AU - Shtrek, Sergey
AU - Igolkina, Yana
AU - Rar, Vera
AU - Zhirakovskaia, E.
AU - Tkachev, Sergey
AU - Kostrykina, Tatiana
AU - Blokhina, Inga
AU - Lentz, Petr
AU - Tikunova, Nina
N1 - Funding Information: The work was supported by Russian State funded budget project of ICBFM SB RAS # АААА-А17-117020210027-9. Publisher Copyright: © 2019 Elsevier GmbH Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/10
Y1 - 2019/10
N2 - North Asian tick-typhus (NATT), also known as Siberian tick typhus, is the main tick-borne rickettsiosis in Siberia, Russia. Recently, a fatal infection in a four-year-old girl with typical tick-borne rickettsiosis symptoms (fever, rash, eschar at the site of the tick bite, myalgia) and meningeal syndrome was registered. In order to identify the etiology of this infection, blood and brain samples from the patient were examined for the presence of a wide range of tick-transmitted agents and enteric viruses by polymerase chain reaction with subsequent sequencing. Rickettsia sibirica subsp. sibirica and “Candidatus Rickettsia tarasevichiae” DNA was identified in both blood and brain samples. Rickettsia sibirica was characterized by the gltA, ompA and ompB genes, and “Candidatus R. tarasevichiae” was characterized by the gltA and ompB genes. We report the first case of mixed R. sibirica and “Candidatus R. tarasevichiae” human infection with a fatal outcome in Russia.
AB - North Asian tick-typhus (NATT), also known as Siberian tick typhus, is the main tick-borne rickettsiosis in Siberia, Russia. Recently, a fatal infection in a four-year-old girl with typical tick-borne rickettsiosis symptoms (fever, rash, eschar at the site of the tick bite, myalgia) and meningeal syndrome was registered. In order to identify the etiology of this infection, blood and brain samples from the patient were examined for the presence of a wide range of tick-transmitted agents and enteric viruses by polymerase chain reaction with subsequent sequencing. Rickettsia sibirica subsp. sibirica and “Candidatus Rickettsia tarasevichiae” DNA was identified in both blood and brain samples. Rickettsia sibirica was characterized by the gltA, ompA and ompB genes, and “Candidatus R. tarasevichiae” was characterized by the gltA and ompB genes. We report the first case of mixed R. sibirica and “Candidatus R. tarasevichiae” human infection with a fatal outcome in Russia.
KW - Candidatus Rickettsia tarasevichiae
KW - Rickettsia sibirica
KW - Rickettsiosis
KW - Rickettsia/isolation & purification
KW - Humans
KW - Fatal Outcome
KW - Siberia
KW - Child, Preschool
KW - Female
KW - Tick-Borne Diseases/diagnosis
KW - Spotted Fever Group Rickettsiosis/diagnosis
KW - Coinfection/diagnosis
UR - http://www.scopus.com/inward/record.url?scp=85071431703&partnerID=8YFLogxK
U2 - 10.1016/j.ttbdis.2019.101278
DO - 10.1016/j.ttbdis.2019.101278
M3 - Article
C2 - 31477530
AN - SCOPUS:85071431703
VL - 10
JO - Ticks and Tick-borne Diseases
JF - Ticks and Tick-borne Diseases
SN - 1877-959X
IS - 6
M1 - 101278
ER -
ID: 27699005