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A 6-day combined wake and light therapy trial for unipolar depression. / Danilenko, Konstantin V.; Lebedinskaia, Maria Y.; Gadetskaia, Evgenia V. et al.

In: Journal of Affective Disorders, Vol. 259, 01.12.2019, p. 355-361.

Research output: Contribution to journalArticlepeer-review

Harvard

Danilenko, KV, Lebedinskaia, MY, Gadetskaia, EV, Markov, AA, Ivanova, YA & Aftanas, LI 2019, 'A 6-day combined wake and light therapy trial for unipolar depression', Journal of Affective Disorders, vol. 259, pp. 355-361. https://doi.org/10.1016/j.jad.2019.08.051

APA

Danilenko, K. V., Lebedinskaia, M. Y., Gadetskaia, E. V., Markov, A. A., Ivanova, Y. A., & Aftanas, L. I. (2019). A 6-day combined wake and light therapy trial for unipolar depression. Journal of Affective Disorders, 259, 355-361. https://doi.org/10.1016/j.jad.2019.08.051

Vancouver

Danilenko KV, Lebedinskaia MY, Gadetskaia EV, Markov AA, Ivanova YA, Aftanas LI. A 6-day combined wake and light therapy trial for unipolar depression. Journal of Affective Disorders. 2019 Dec 1;259:355-361. Epub 2019 Aug 19. doi: 10.1016/j.jad.2019.08.051

Author

Danilenko, Konstantin V. ; Lebedinskaia, Maria Y. ; Gadetskaia, Evgenia V. et al. / A 6-day combined wake and light therapy trial for unipolar depression. In: Journal of Affective Disorders. 2019 ; Vol. 259. pp. 355-361.

BibTeX

@article{142160e6d9af4997a22128f7dbdcb9a9,
title = "A 6-day combined wake and light therapy trial for unipolar depression",
abstract = "Background: There are a dozen studies on double or triple chronotherapy in depression (sleep deprivation [wake therapy] + light therapy + sleep advance/stabilization). We investigated efficacy and feasibility of a modified triple chronotherapy protocol. Methods: Thirty-five hospitalized patients with moderately severe non-seasonal depressive disorder, mostly free from antidepressants, underwent a 6-day protocol consisting of partial sleep deprivation late in the second half of the night (from 4:00 to 8:00) in a light therapy room (blue-enhanced white light increased hourly from 600→1300→2200→2800 lx) alternating with recovery nights with morning light treatment from 7:00 to 8:00. Patients were randomized to wear glasses with no filter (clear, N = 19) or filtering blue wavelength (orange-appearance, light intensity diminution by ∼70%, N = 16) during the treatments. Sleep was targeted to be shifted at least 1 h earlier. Depression was scored using HDRS-17 (Hamilton Depression Rating Scale) and BDI-II (Beck Depression Inventory-II) – before and after the 6-days treatment, HDRS-6-SR – daily, and visual analogue scales (VAS) for mood and energy – several times every day. Results: Depression levels significantly declined following the first night and after 6-days treatment, with no difference between white and orange lights. Nevertheless, some superiority of white light emerged with respect to response rate (mood VAS), immediate effect during the 4-h treatment sessions (energy VAS), and expected treatment outcomes. All patients successfully advanced bedtime/wake-up (by 30–40 minutes) and resisted naps during daytime. Limitations: Relatively small sample size. Conclusions: The modified triple chronotherapy was well tolerated and improved depression. Light spectrum/intensity plays some role in the response.",
keywords = "Blue-enhanced light, Chronotherapy, Partial sleep deprivation, Unipolar depression, METAANALYSIS, SLEEP-DEPRIVATION, BRIGHT",
author = "Danilenko, {Konstantin V.} and Lebedinskaia, {Maria Y.} and Gadetskaia, {Evgenia V.} and Markov, {Alexei A.} and Ivanova, {Yana A.} and Aftanas, {Lyubomir I.}",
note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",
year = "2019",
month = dec,
day = "1",
doi = "10.1016/j.jad.2019.08.051",
language = "English",
volume = "259",
pages = "355--361",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - A 6-day combined wake and light therapy trial for unipolar depression

AU - Danilenko, Konstantin V.

AU - Lebedinskaia, Maria Y.

AU - Gadetskaia, Evgenia V.

AU - Markov, Alexei A.

AU - Ivanova, Yana A.

AU - Aftanas, Lyubomir I.

N1 - Publisher Copyright: © 2019 Elsevier B.V.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Background: There are a dozen studies on double or triple chronotherapy in depression (sleep deprivation [wake therapy] + light therapy + sleep advance/stabilization). We investigated efficacy and feasibility of a modified triple chronotherapy protocol. Methods: Thirty-five hospitalized patients with moderately severe non-seasonal depressive disorder, mostly free from antidepressants, underwent a 6-day protocol consisting of partial sleep deprivation late in the second half of the night (from 4:00 to 8:00) in a light therapy room (blue-enhanced white light increased hourly from 600→1300→2200→2800 lx) alternating with recovery nights with morning light treatment from 7:00 to 8:00. Patients were randomized to wear glasses with no filter (clear, N = 19) or filtering blue wavelength (orange-appearance, light intensity diminution by ∼70%, N = 16) during the treatments. Sleep was targeted to be shifted at least 1 h earlier. Depression was scored using HDRS-17 (Hamilton Depression Rating Scale) and BDI-II (Beck Depression Inventory-II) – before and after the 6-days treatment, HDRS-6-SR – daily, and visual analogue scales (VAS) for mood and energy – several times every day. Results: Depression levels significantly declined following the first night and after 6-days treatment, with no difference between white and orange lights. Nevertheless, some superiority of white light emerged with respect to response rate (mood VAS), immediate effect during the 4-h treatment sessions (energy VAS), and expected treatment outcomes. All patients successfully advanced bedtime/wake-up (by 30–40 minutes) and resisted naps during daytime. Limitations: Relatively small sample size. Conclusions: The modified triple chronotherapy was well tolerated and improved depression. Light spectrum/intensity plays some role in the response.

AB - Background: There are a dozen studies on double or triple chronotherapy in depression (sleep deprivation [wake therapy] + light therapy + sleep advance/stabilization). We investigated efficacy and feasibility of a modified triple chronotherapy protocol. Methods: Thirty-five hospitalized patients with moderately severe non-seasonal depressive disorder, mostly free from antidepressants, underwent a 6-day protocol consisting of partial sleep deprivation late in the second half of the night (from 4:00 to 8:00) in a light therapy room (blue-enhanced white light increased hourly from 600→1300→2200→2800 lx) alternating with recovery nights with morning light treatment from 7:00 to 8:00. Patients were randomized to wear glasses with no filter (clear, N = 19) or filtering blue wavelength (orange-appearance, light intensity diminution by ∼70%, N = 16) during the treatments. Sleep was targeted to be shifted at least 1 h earlier. Depression was scored using HDRS-17 (Hamilton Depression Rating Scale) and BDI-II (Beck Depression Inventory-II) – before and after the 6-days treatment, HDRS-6-SR – daily, and visual analogue scales (VAS) for mood and energy – several times every day. Results: Depression levels significantly declined following the first night and after 6-days treatment, with no difference between white and orange lights. Nevertheless, some superiority of white light emerged with respect to response rate (mood VAS), immediate effect during the 4-h treatment sessions (energy VAS), and expected treatment outcomes. All patients successfully advanced bedtime/wake-up (by 30–40 minutes) and resisted naps during daytime. Limitations: Relatively small sample size. Conclusions: The modified triple chronotherapy was well tolerated and improved depression. Light spectrum/intensity plays some role in the response.

KW - Blue-enhanced light

KW - Chronotherapy

KW - Partial sleep deprivation

KW - Unipolar depression

KW - METAANALYSIS

KW - SLEEP-DEPRIVATION

KW - BRIGHT

UR - http://www.scopus.com/inward/record.url?scp=85071322098&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2019.08.051

DO - 10.1016/j.jad.2019.08.051

M3 - Article

C2 - 31472393

AN - SCOPUS:85071322098

VL - 259

SP - 355

EP - 361

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -

ID: 21345360