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8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals? / Kruchinin, Alexander A; Kamzeeva, Polina N; Zharkov, Dmitry O et al.

In: International Journal of Molecular Sciences, Vol. 25, No. 2, 1342, 22.01.2024.

Research output: Contribution to journal › Review article › peer-review

Harvard

Kruchinin, AA, Kamzeeva, PN, Zharkov, DO, Aralov, AV & Makarova, AV 2024, '8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals?', International Journal of Molecular Sciences, vol. 25, no. 2, 1342. https://doi.org/10.3390/ijms25021342

APA

Kruchinin, A. A., Kamzeeva, P. N., Zharkov, D. O., Aralov, A. V., & Makarova, A. V. (2024). 8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals? International Journal of Molecular Sciences, 25(2), [1342]. https://doi.org/10.3390/ijms25021342

Vancouver

Kruchinin AA, Kamzeeva PN, Zharkov DO, Aralov AV, Makarova AV. 8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals? International Journal of Molecular Sciences. 2024 Jan 22;25(2):1342. doi: 10.3390/ijms25021342

Author

Kruchinin, Alexander A ; Kamzeeva, Polina N ; Zharkov, Dmitry O et al. / 8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals?. In: International Journal of Molecular Sciences. 2024 ; Vol. 25, No. 2.

BibTeX

@article{27efbd8c234d4bd9a0157cbe477e75bf,
title = "8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals?",
abstract = "Numerous studies have shown that oxidative modifications of guanine (7,8-dihydro-8-oxoguanine, 8-oxoG) can affect cellular functions. 7,8-Dihydro-8-oxoadenine (8-oxoA) is another abundant paradigmatic ambiguous nucleobase but findings reported on the mutagenicity of 8-oxoA in bacterial and eukaryotic cells are incomplete and contradictory. Although several genotoxic studies have demonstrated the mutagenic potential of 8-oxoA in eukaryotic cells, very little biochemical and bioinformatics data about the mechanism of 8-oxoA-induced mutagenesis are available. In this review, we discuss dual coding properties of 8-oxoA, summarize historical and recent genotoxicity and biochemical studies, and address the main protective cellular mechanisms of response to 8-oxoA. We also discuss the available structural data for 8-oxoA bypass by different DNA polymerases as well as the mechanisms of 8-oxoA recognition by DNA repair enzymes.",
keywords = "Animals, Adenine/chemistry, DNA-Directed DNA Polymerase/metabolism, Oxidative Stress, DNA Damage, Mutagens, Mammals/metabolism, DNA Repair, 7,8-dihydro-8-oxoadenine, translesion DNA synthesis, base excision repair, mutagenesis, DNA polymerases, DNA glycosylases",
author = "Kruchinin, {Alexander A} and Kamzeeva, {Polina N} and Zharkov, {Dmitry O} and Aralov, {Andrey V} and Makarova, {Alena V}",
note = "The study was supported by The Russian Scientific Foundation grant 23-14-00209 to A.V.M. D.O.Z. acknowledges funding from the Russian Ministry of Science and Higher Education (project 075-15-2022-263).",
year = "2024",
month = jan,
day = "22",
doi = "10.3390/ijms25021342",
language = "English",
volume = "25",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

RIS

TY - JOUR

T1 - 8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals?

AU - Kruchinin, Alexander A

AU - Kamzeeva, Polina N

AU - Zharkov, Dmitry O

AU - Aralov, Andrey V

AU - Makarova, Alena V

N1 - The study was supported by The Russian Scientific Foundation grant 23-14-00209 to A.V.M. D.O.Z. acknowledges funding from the Russian Ministry of Science and Higher Education (project 075-15-2022-263).

PY - 2024/1/22

Y1 - 2024/1/22

N2 - Numerous studies have shown that oxidative modifications of guanine (7,8-dihydro-8-oxoguanine, 8-oxoG) can affect cellular functions. 7,8-Dihydro-8-oxoadenine (8-oxoA) is another abundant paradigmatic ambiguous nucleobase but findings reported on the mutagenicity of 8-oxoA in bacterial and eukaryotic cells are incomplete and contradictory. Although several genotoxic studies have demonstrated the mutagenic potential of 8-oxoA in eukaryotic cells, very little biochemical and bioinformatics data about the mechanism of 8-oxoA-induced mutagenesis are available. In this review, we discuss dual coding properties of 8-oxoA, summarize historical and recent genotoxicity and biochemical studies, and address the main protective cellular mechanisms of response to 8-oxoA. We also discuss the available structural data for 8-oxoA bypass by different DNA polymerases as well as the mechanisms of 8-oxoA recognition by DNA repair enzymes.

AB - Numerous studies have shown that oxidative modifications of guanine (7,8-dihydro-8-oxoguanine, 8-oxoG) can affect cellular functions. 7,8-Dihydro-8-oxoadenine (8-oxoA) is another abundant paradigmatic ambiguous nucleobase but findings reported on the mutagenicity of 8-oxoA in bacterial and eukaryotic cells are incomplete and contradictory. Although several genotoxic studies have demonstrated the mutagenic potential of 8-oxoA in eukaryotic cells, very little biochemical and bioinformatics data about the mechanism of 8-oxoA-induced mutagenesis are available. In this review, we discuss dual coding properties of 8-oxoA, summarize historical and recent genotoxicity and biochemical studies, and address the main protective cellular mechanisms of response to 8-oxoA. We also discuss the available structural data for 8-oxoA bypass by different DNA polymerases as well as the mechanisms of 8-oxoA recognition by DNA repair enzymes.

KW - Animals

KW - Adenine/chemistry

KW - DNA-Directed DNA Polymerase/metabolism

KW - Oxidative Stress

KW - DNA Damage

KW - Mutagens

KW - Mammals/metabolism

KW - DNA Repair

KW - 7,8-dihydro-8-oxoadenine

KW - translesion DNA synthesis

KW - base excision repair

KW - mutagenesis

KW - DNA polymerases

KW - DNA glycosylases

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85183376672&origin=inward&txGid=7baf402a74d4d73135ff40e30571be22

UR - https://www.mendeley.com/catalogue/01e6bb26-e380-36b7-86e2-7ec5f56f263b/

U2 - 10.3390/ijms25021342

DO - 10.3390/ijms25021342

M3 - Review article

C2 - 38279342

VL - 25

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 2

M1 - 1342

ER -

ID: 60452173