Standard

3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains. / Taratayko, Andrey I.; Glazachev, Yurii I.; Eltsov, Ilia V. et al.

In: Molecules, Vol. 27, No. 6, 1922, 01.03.2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Taratayko, AI, Glazachev, YI, Eltsov, IV, Chernyak, EI & Kirilyuk, IA 2022, '3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains', Molecules, vol. 27, no. 6, 1922. https://doi.org/10.3390/molecules27061922

APA

Taratayko, A. I., Glazachev, Y. I., Eltsov, I. V., Chernyak, E. I., & Kirilyuk, I. A. (2022). 3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains. Molecules, 27(6), [1922]. https://doi.org/10.3390/molecules27061922

Vancouver

Taratayko AI, Glazachev YI, Eltsov IV, Chernyak EI, Kirilyuk IA. 3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains. Molecules. 2022 Mar 1;27(6):1922. doi: 10.3390/molecules27061922

Author

Taratayko, Andrey I. ; Glazachev, Yurii I. ; Eltsov, Ilia V. et al. / 3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains. In: Molecules. 2022 ; Vol. 27, No. 6.

BibTeX

@article{1573854e27b542aea0387b9a0a5f9f47,
title = "3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains",
abstract = "Pyrrolidine nitroxides with four bulky alkyl substituents adjacent to N–O group are known for their high resistance to bioreduction. The 3,4-unsubstituted 2-tert-butyl-2-ethylpyrrolidine-1-oxyls were prepared from the corresponding 2-tert-butyl-1-pyrroline-1-oxides via either the addition of ethinylmagnesium bromide with subsequent hydrogenation or via treatment with ethyllithium. The new nitroxides showed excellent stability to reduction with ascorbate with no evidence for additional large hyperfine couplings in the EPR spectra.",
keywords = "nitrones, nitroxides, organometallic compounds, pyrrolidine, reduction kinetics, Ascorbic Acid, Bromides, Pyrrolidines, Dietary Fiber, Hydrogenation",
author = "Taratayko, {Andrey I.} and Glazachev, {Yurii I.} and Eltsov, {Ilia V.} and Chernyak, {Elena I.} and Kirilyuk, {Igor A.}",
note = "Funding Information: Funding: This research was funded by the Russian Scientific Foundation (grant number 21-73-00281). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = mar,
day = "1",
doi = "10.3390/molecules27061922",
language = "English",
volume = "27",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",

}

RIS

TY - JOUR

T1 - 3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains

AU - Taratayko, Andrey I.

AU - Glazachev, Yurii I.

AU - Eltsov, Ilia V.

AU - Chernyak, Elena I.

AU - Kirilyuk, Igor A.

N1 - Funding Information: Funding: This research was funded by the Russian Scientific Foundation (grant number 21-73-00281). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/3/1

Y1 - 2022/3/1

N2 - Pyrrolidine nitroxides with four bulky alkyl substituents adjacent to N–O group are known for their high resistance to bioreduction. The 3,4-unsubstituted 2-tert-butyl-2-ethylpyrrolidine-1-oxyls were prepared from the corresponding 2-tert-butyl-1-pyrroline-1-oxides via either the addition of ethinylmagnesium bromide with subsequent hydrogenation or via treatment with ethyllithium. The new nitroxides showed excellent stability to reduction with ascorbate with no evidence for additional large hyperfine couplings in the EPR spectra.

AB - Pyrrolidine nitroxides with four bulky alkyl substituents adjacent to N–O group are known for their high resistance to bioreduction. The 3,4-unsubstituted 2-tert-butyl-2-ethylpyrrolidine-1-oxyls were prepared from the corresponding 2-tert-butyl-1-pyrroline-1-oxides via either the addition of ethinylmagnesium bromide with subsequent hydrogenation or via treatment with ethyllithium. The new nitroxides showed excellent stability to reduction with ascorbate with no evidence for additional large hyperfine couplings in the EPR spectra.

KW - nitrones

KW - nitroxides

KW - organometallic compounds

KW - pyrrolidine

KW - reduction kinetics

KW - Ascorbic Acid

KW - Bromides

KW - Pyrrolidines

KW - Dietary Fiber

KW - Hydrogenation

UR - http://www.scopus.com/inward/record.url?scp=85126912293&partnerID=8YFLogxK

U2 - 10.3390/molecules27061922

DO - 10.3390/molecules27061922

M3 - Article

C2 - 35335285

AN - SCOPUS:85126912293

VL - 27

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 6

M1 - 1922

ER -

ID: 35769196