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1H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media. / Mirzaeva, Irina Valerievna; Andrienko, Irina Valentinovna; Kovalenko, Ekaterina Aleksandrovna et al.

In: Applied Magnetic Resonance, Vol. 50, No. 11, 01.11.2019, p. 1267-1276.

Research output: Contribution to journal › Article › peer-review

Harvard

Mirzaeva, IV, Andrienko, IV, Kovalenko, EA, Pashkina, EA & Aktanova, AA 2019, '1H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media', Applied Magnetic Resonance, vol. 50, no. 11, pp. 1267-1276. https://doi.org/10.1007/s00723-019-01147-3

APA

Mirzaeva, I. V., Andrienko, I. V., Kovalenko, E. A., Pashkina, E. A., & Aktanova, A. A. (2019). 1H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media. Applied Magnetic Resonance, 50(11), 1267-1276. https://doi.org/10.1007/s00723-019-01147-3

Vancouver

Mirzaeva IV, Andrienko IV, Kovalenko EA, Pashkina EA, Aktanova AA. 1H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media. Applied Magnetic Resonance. 2019 Nov 1;50(11):1267-1276. doi: 10.1007/s00723-019-01147-3

Author

Mirzaeva, Irina Valerievna ; Andrienko, Irina Valentinovna ; Kovalenko, Ekaterina Aleksandrovna et al. / 1H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media. In: Applied Magnetic Resonance. 2019 ; Vol. 50, No. 11. pp. 1267-1276.

BibTeX

@article{dc1b71a22bca4b3783efc23752f30667,
title = "1H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media",
abstract = "The aquation of carboplatin, a second-generation Pt(II)-based antitumor drug, in two biologically relevant media (PBS buffer solution and RPMI-1640 medium for cell growth) has been studied by means of 1H nuclear magnetic resonance spectroscopy. The effect of the macrocyclic cavitand cucurbit[7]uril on the carboplatin aquation rates in these two types of media has also been studied. Although, the cucurbit[7]uril does not form stable inclusion complex with carboplatin, it greatly affects the carboplatin aquation rates, presumably, through the two mechanisms: prevention of the carboplatin dimer formation and encapsulation of some components of the medium.",
keywords = "ANTICANCER DRUG CARBOPLATIN, COMPLEXES, OXALIPLATIN, RECOGNITION, HYDROLYSIS, STABILITY, KINETICS, BINDING, ACID",
author = "Mirzaeva, {Irina Valerievna} and Andrienko, {Irina Valentinovna} and Kovalenko, {Ekaterina Aleksandrovna} and Pashkina, {Ekaterina Aleksandrovna} and Aktanova, {Alina Aleksandrovna}",
note = "Publisher Copyright: {\textcopyright} 2019, Springer-Verlag GmbH Austria, part of Springer Nature. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
month = nov,
day = "1",
doi = "10.1007/s00723-019-01147-3",
language = "English",
volume = "50",
pages = "1267--1276",
journal = "Applied Magnetic Resonance",
issn = "0937-9347",
publisher = "Springer-Verlag GmbH and Co. KG",
number = "11",

}

RIS

TY - JOUR

T1 - 1H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media

AU - Mirzaeva, Irina Valerievna

AU - Andrienko, Irina Valentinovna

AU - Kovalenko, Ekaterina Aleksandrovna

AU - Pashkina, Ekaterina Aleksandrovna

AU - Aktanova, Alina Aleksandrovna

N1 - Publisher Copyright: © 2019, Springer-Verlag GmbH Austria, part of Springer Nature. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - The aquation of carboplatin, a second-generation Pt(II)-based antitumor drug, in two biologically relevant media (PBS buffer solution and RPMI-1640 medium for cell growth) has been studied by means of 1H nuclear magnetic resonance spectroscopy. The effect of the macrocyclic cavitand cucurbit[7]uril on the carboplatin aquation rates in these two types of media has also been studied. Although, the cucurbit[7]uril does not form stable inclusion complex with carboplatin, it greatly affects the carboplatin aquation rates, presumably, through the two mechanisms: prevention of the carboplatin dimer formation and encapsulation of some components of the medium.

AB - The aquation of carboplatin, a second-generation Pt(II)-based antitumor drug, in two biologically relevant media (PBS buffer solution and RPMI-1640 medium for cell growth) has been studied by means of 1H nuclear magnetic resonance spectroscopy. The effect of the macrocyclic cavitand cucurbit[7]uril on the carboplatin aquation rates in these two types of media has also been studied. Although, the cucurbit[7]uril does not form stable inclusion complex with carboplatin, it greatly affects the carboplatin aquation rates, presumably, through the two mechanisms: prevention of the carboplatin dimer formation and encapsulation of some components of the medium.

KW - ANTICANCER DRUG CARBOPLATIN

KW - COMPLEXES

KW - OXALIPLATIN

KW - RECOGNITION

KW - HYDROLYSIS

KW - STABILITY

KW - KINETICS

KW - BINDING

KW - ACID

UR - http://www.scopus.com/inward/record.url?scp=85068845849&partnerID=8YFLogxK

U2 - 10.1007/s00723-019-01147-3

DO - 10.1007/s00723-019-01147-3

M3 - Article

AN - SCOPUS:85068845849

VL - 50

SP - 1267

EP - 1276

JO - Applied Magnetic Resonance

JF - Applied Magnetic Resonance

SN - 0937-9347

IS - 11

ER -

ID: 20849571