TY - JOUR

T1 - Клинико-лабораторные особенности поражений ногтей у пациентов, самостоятельно применявших для лечения наружные противогрибковые средства

AU - Chasnyk, A. S.

AU - Shipilova, N. A.

AU - Pakhomova, V. V.

AU - Gubanova, E. G.

AU - Sergeeva, I. G.

AU - Позднякова, О.Н.

PY - 2024

Y1 - 2024

N2 - Background. Alteration of nail plates is a frequent situation in the dermatologist’s practice. Patients often use various antifungal drugs before seeking specialized care, that doesn’t lead to recovery and is found when taking history. Objective. To study clinical and laboratory features of nail lesions in patients who used external antifungal drugs for the treatment of nail plates by themselves. Material and methods. The study conducted at the Novosibirsk Regional Clinical Dermatovenerologic Dispensary included 41 patients aged 33––85 years (mean age 61.3±11.3 years), among whom 22 (53.7%) were women and 19 (46.3%) –– men. All patients used external antifungal drugs by themselves before seeking dermatological care and had various alterations of nail plates. Clinical, microscopic and cultural examinations were applied for differential diagnosis of mycosis and nail dystrophy. Results. Nail mycosis has been found in 78.4% of cases among 37 patients who underwent a complete laboratory examination. Among them, fungal mycelium has been identified in 51.7% of patients only in the second or third microscopic examination, fungi colonies development on nutrient media has been revealed in 13.8% of patients with negative microscopy results. A change in the color of the nail, uneven edge, onycholysis and hyperkeratosis of different degrees were observed in clinical picture of both onychomycosis and onychodystrophy. All patients had a combination of two or more clinical signs. Conclusion. The self-use of external antifungal drugs in onychomycosis independently of active substance does not lead to clinical and mycological recovery. The previous self-treatment makes laboratory confirmation of fungal nails lesion difficult and requires combined application of microscopic and cultural methods of laboratory diagnosis.

AB - Background. Alteration of nail plates is a frequent situation in the dermatologist’s practice. Patients often use various antifungal drugs before seeking specialized care, that doesn’t lead to recovery and is found when taking history. Objective. To study clinical and laboratory features of nail lesions in patients who used external antifungal drugs for the treatment of nail plates by themselves. Material and methods. The study conducted at the Novosibirsk Regional Clinical Dermatovenerologic Dispensary included 41 patients aged 33––85 years (mean age 61.3±11.3 years), among whom 22 (53.7%) were women and 19 (46.3%) –– men. All patients used external antifungal drugs by themselves before seeking dermatological care and had various alterations of nail plates. Clinical, microscopic and cultural examinations were applied for differential diagnosis of mycosis and nail dystrophy. Results. Nail mycosis has been found in 78.4% of cases among 37 patients who underwent a complete laboratory examination. Among them, fungal mycelium has been identified in 51.7% of patients only in the second or third microscopic examination, fungi colonies development on nutrient media has been revealed in 13.8% of patients with negative microscopy results. A change in the color of the nail, uneven edge, onycholysis and hyperkeratosis of different degrees were observed in clinical picture of both onychomycosis and onychodystrophy. All patients had a combination of two or more clinical signs. Conclusion. The self-use of external antifungal drugs in onychomycosis independently of active substance does not lead to clinical and mycological recovery. The previous self-treatment makes laboratory confirmation of fungal nails lesion difficult and requires combined application of microscopic and cultural methods of laboratory diagnosis.

KW - Candida krusei

KW - external antifungal drugs

KW - laboratory diagnosis of onychomycosis

KW - onychodystrophy

KW - onychomycosis

KW - self-treatment

KW - Candida krusei

KW - external antifungal drugs

KW - laboratory diagnosis of onychomycosis

KW - onychodystrophy

KW - onychomycosis

KW - self-treatment

UR - https://www.mendeley.com/catalogue/8dd68e6c-9e11-3834-9b32-05589de2b687/

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85213532298&origin=inward&txGid=3b7a634aa482662aae27513b992a288d

U2 - 10.17116/klinderma202423061724

DO - 10.17116/klinderma202423061724

M3 - статья

VL - 23

SP - 724

EP - 729

JO - Клиническая дерматология и венерология

JF - Клиническая дерматология и венерология

SN - 1997-2849

IS - 6

ER -