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Фармакокинетика, побочные эффекты, лекарственные формы, лекарственные взаимодействия куркумина. / Shrayner, E. V.; Nikolaychuk, K. M.; Khvostov, M. V. et al.

In: Экспериментальная и клиническая гастроэнтерология, Vol. 9, 2024, p. 147-160.

Research output: Contribution to journal › Article › peer-review

Harvard

Shrayner, EV, Nikolaychuk, KM, Khvostov, MV, Pavlova, AV, Tolstikova, TG, Veremenko, AS, Levchenko, ID, Platonova, PY, Novikova, MF, Tumas, AS, Vergunova, EE, Lukichev, DA, Sergeev, DA, Khavkin, AI, Pokushalov, EA & Kudlai, DA 2024, 'Фармакокинетика, побочные эффекты, лекарственные формы, лекарственные взаимодействия куркумина', Экспериментальная и клиническая гастроэнтерология, vol. 9, pp. 147-160. https://doi.org/10.31146/1682-8658-ecg-229-9-147-160

APA

Shrayner, E. V., Nikolaychuk, K. M., Khvostov, M. V., Pavlova, A. V., Tolstikova, T. G., Veremenko, A. S., Levchenko, I. D., Platonova, P. Y., Novikova, M. F., Tumas, A. S., Vergunova, E. E., Lukichev, D. A., Sergeev, D. A., Khavkin, A. I., Pokushalov, E. A., & Kudlai, D. A. (2024). Фармакокинетика, побочные эффекты, лекарственные формы, лекарственные взаимодействия куркумина. Экспериментальная и клиническая гастроэнтерология, 9, 147-160. https://doi.org/10.31146/1682-8658-ecg-229-9-147-160

Vancouver

Shrayner EV, Nikolaychuk KM, Khvostov MV, Pavlova AV, Tolstikova TG, Veremenko AS et al. Фармакокинетика, побочные эффекты, лекарственные формы, лекарственные взаимодействия куркумина. Экспериментальная и клиническая гастроэнтерология. 2024;9:147-160. doi: 10.31146/1682-8658-ecg-229-9-147-160

Author

Shrayner, E. V. ; Nikolaychuk, K. M. ; Khvostov, M. V. et al. / Фармакокинетика, побочные эффекты, лекарственные формы, лекарственные взаимодействия куркумина. In: Экспериментальная и клиническая гастроэнтерология. 2024 ; Vol. 9. pp. 147-160.

BibTeX

@article{d3f671ebe9a84dd9b81f91004b36b8bc,
title = "Фармакокинетика, побочные эффекты, лекарственные формы, лекарственные взаимодействия куркумина",
abstract = "This review presents current data on the pharmacokinetics, side effects, dosage forms and interactions of curcumin. Curcumin, the major bioactive component of turmeric, has low bioavailability due to its low water solubility, rapid metabolism in the liver and rapid excretion from the body. The main pathways of curcumin metabolism are described, including its reduction and subsequent conjugation with glucuronic acid and sulphates. Side effects of curcumin such as hyperoxaluria, iron deficiency anaemia, hepatotoxicity, arrhythmias, allergic reactions and potential carcinogenic properties are discussed. Various dosage forms of curcumin developed to enhance its bioavailability are discussed, including liposomes, nanoparticles, hydrogels and phytosomes. Particular attention is given to the drug interactions of curcumin with chemotherapeutic agents such as 5-fluorouracil, vincristine, gemcitabine, adriamycin and cisplatin, as well as with hypolipidaemic agents, antiaggregants and anticoagulants. These data highlight the need for further studies to optimise the therapeutic use of curcumin and minimise its side effects.",
keywords = "curcumin, dosage forms, drug interactions, pharmacokinetics, side effects",
author = "Shrayner, {E. V.} and Nikolaychuk, {K. M.} and Khvostov, {M. V.} and Pavlova, {A. V.} and Tolstikova, {T. G.} and Veremenko, {A. S.} and Levchenko, {I. D.} and Platonova, {P. Ya} and Novikova, {M. F.} and Tumas, {A. S.} and Vergunova, {E. E.} and Lukichev, {D. A.} and Sergeev, {D. A.} and Khavkin, {A. I.} and Pokushalov, {E. A.} and Kudlai, {D. A.}",
note = "Shrayner E.V., Nikolaychuk K.M., Khvostov M.V., Pavlova A.V., Tolstikova T.G., Veremenko A.S., Levchenko I.D., Platonova P.Ya., Novikova M.F., Tumas A.S., Vergunova E.E., Lukichev D.A., Sergeev D.A., Khavkin A.I., Pokushalov E.A., Kudlai D.A. Pharmacokinetics, side effects, dosage forms, drug interactions of curcu-mine. Experimental and Clinical Gastroenterology. 2024;(9):147-160. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-229-9-147-160 ",
year = "2024",
doi = "10.31146/1682-8658-ecg-229-9-147-160",
language = "русский",
volume = "9",
pages = "147--160",
journal = "Экспериментальная и клиническая гастроэнтерология",
issn = "1682-8658",
publisher = "Научное общество гастроэнтерологов России (Москва)",

}

RIS

TY - JOUR

T1 - Фармакокинетика, побочные эффекты, лекарственные формы, лекарственные взаимодействия куркумина

AU - Shrayner, E. V.

AU - Nikolaychuk, K. M.

AU - Khvostov, M. V.

AU - Pavlova, A. V.

AU - Tolstikova, T. G.

AU - Veremenko, A. S.

AU - Levchenko, I. D.

AU - Platonova, P. Ya

AU - Novikova, M. F.

AU - Tumas, A. S.

AU - Vergunova, E. E.

AU - Lukichev, D. A.

AU - Sergeev, D. A.

AU - Khavkin, A. I.

AU - Pokushalov, E. A.

AU - Kudlai, D. A.

N1 - Shrayner E.V., Nikolaychuk K.M., Khvostov M.V., Pavlova A.V., Tolstikova T.G., Veremenko A.S., Levchenko I.D., Platonova P.Ya., Novikova M.F., Tumas A.S., Vergunova E.E., Lukichev D.A., Sergeev D.A., Khavkin A.I., Pokushalov E.A., Kudlai D.A. Pharmacokinetics, side effects, dosage forms, drug interactions of curcu-mine. Experimental and Clinical Gastroenterology. 2024;(9):147-160. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-229-9-147-160

PY - 2024

Y1 - 2024

N2 - This review presents current data on the pharmacokinetics, side effects, dosage forms and interactions of curcumin. Curcumin, the major bioactive component of turmeric, has low bioavailability due to its low water solubility, rapid metabolism in the liver and rapid excretion from the body. The main pathways of curcumin metabolism are described, including its reduction and subsequent conjugation with glucuronic acid and sulphates. Side effects of curcumin such as hyperoxaluria, iron deficiency anaemia, hepatotoxicity, arrhythmias, allergic reactions and potential carcinogenic properties are discussed. Various dosage forms of curcumin developed to enhance its bioavailability are discussed, including liposomes, nanoparticles, hydrogels and phytosomes. Particular attention is given to the drug interactions of curcumin with chemotherapeutic agents such as 5-fluorouracil, vincristine, gemcitabine, adriamycin and cisplatin, as well as with hypolipidaemic agents, antiaggregants and anticoagulants. These data highlight the need for further studies to optimise the therapeutic use of curcumin and minimise its side effects.

AB - This review presents current data on the pharmacokinetics, side effects, dosage forms and interactions of curcumin. Curcumin, the major bioactive component of turmeric, has low bioavailability due to its low water solubility, rapid metabolism in the liver and rapid excretion from the body. The main pathways of curcumin metabolism are described, including its reduction and subsequent conjugation with glucuronic acid and sulphates. Side effects of curcumin such as hyperoxaluria, iron deficiency anaemia, hepatotoxicity, arrhythmias, allergic reactions and potential carcinogenic properties are discussed. Various dosage forms of curcumin developed to enhance its bioavailability are discussed, including liposomes, nanoparticles, hydrogels and phytosomes. Particular attention is given to the drug interactions of curcumin with chemotherapeutic agents such as 5-fluorouracil, vincristine, gemcitabine, adriamycin and cisplatin, as well as with hypolipidaemic agents, antiaggregants and anticoagulants. These data highlight the need for further studies to optimise the therapeutic use of curcumin and minimise its side effects.

KW - curcumin

KW - dosage forms

KW - drug interactions

KW - pharmacokinetics

KW - side effects

UR - https://www.mendeley.com/catalogue/01c1fc03-c955-38c1-97da-37a7645e829e/

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-86000500506&origin=inward&txGid=409846d0e46c180229ae57c9a1aae215

U2 - 10.31146/1682-8658-ecg-229-9-147-160

DO - 10.31146/1682-8658-ecg-229-9-147-160

M3 - статья

VL - 9

SP - 147

EP - 160

JO - Экспериментальная и клиническая гастроэнтерология

JF - Экспериментальная и клиническая гастроэнтерология

SN - 1682-8658

ER -

ID: 65140270