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  1. 2024

  2. Effect of Short-Term Restraint Stress on the Expression of Genes Associated with the Response to Oxidative Stress in the Hypothalamus of Hypertensive ISIAH and Normotensive WAG Rats

    Makovka, Y. V., Oshchepkov, D. Y., Fedoseeva, L. A., Markel, A. L. & Redina, O. E., Nov 2024, In: Antioxidants. 13, 11, 1302.

    Research output: Contribution to journal › Article › peer-review

  3. Effect of Short-Term Restraint Stress on the Hypothalamic Transcriptome Profiles of Rats with Inherited Stress-Induced Arterial Hypertension (ISIAH) and Normotensive Wistar Albino Glaxo (WAG) Rats

    Oshchepkov, D. Y., Makovka, Y. V., Fedoseeva, L. A., Seryapina, A. A., Markel, A. L. & Redina, O. E., 18 Jun 2024, In: International Journal of Molecular Sciences. 25, 12, 6680.

    Research output: Contribution to journal › Article › peer-review

  4. Urine metabolic profile in rats with arterial hypertension of different genesis

    Sorokoumova, A. A., Seryapina, A. A., Polityko, Y. K., Yanshole, L. V., Tsentalovich, Y. P., Gilinsky, M. A. & Markel, A. L., Jun 2024, In: Vavilovskii Zhurnal Genetiki i Selektsii. 28, 3, p. 299-307 9 p., 4.

    Research output: Contribution to journal › Article › peer-review

  5. Search for Metabolomic Markers of Hypertensive Conditions of Different Genesis: Experimental Study

    Seryapina, А. А., Sorokoumova, А. А., Polityko, Y. K., Yanshole, L. V., Tsentalovich, Y. P., Gilinsky, М. А. & Markel, А. L., 9 May 2024, In: Journal of Evolutionary Biochemistry and Physiology. 60, 1, p. 10-21 12 p.

    Research output: Contribution to journal › Article › peer-review

  6. A Principal Components Analysis and Functional Annotation of Differentially Expressed Genes in Brain Regions of Gray Rats Selected for Tame or Aggressive Behavior

    Chadaeva, I., Kozhemyakina, R., Shikhevich, S., Bogomolov, A., Kondratyuk, E., Ощепков, Д. Ю., Orlov, Y. L. & Markel, A. L., May 2024, In: International Journal of Molecular Sciences. 25, 9, 16 p., 4613.

    Research output: Contribution to journal › Article › peer-review

  7. Restraint Stress-Induced Expression of Fos and Several Related Genes in the Hypothalamus of Hypertensive ISIAH Rats

    Makovka, Y. V., Fedoseeva, L. A., Oshchepkov, D. Y., Markel, A. L. & Redina, O. E., Feb 2024, In: Molecular Biology. 58, 1, p. 62-70 9 p.

    Research output: Contribution to journal › Article › peer-review

  8. Экспрессия гена Fos и некоторых связанных с ним генов в гипоталамусе гипертензивных крыс НИСАГ (ISIAH) при воздействии рестрикционного стресса

    Makovka, Y. V., Fedoseeva, L. A., Oshchepkov, D. Y., Markel, A. L. & Redina, O. E., 1 Jan 2024, In: Molekulyarnaya Biologiya. 58, 1, p. 78-87 10 p.

    Research output: Contribution to journal › Article › peer-review

  9. 2023

  10. RatDEGdb: a knowledge base of differentially expressed genes in the rat as a model object in biomedical research

    Chadaeva, I. V., Filonov, S. V., Zolotareva, K. A., Khandaev, B. M., Ershov, N. I., Podkolodnyy, N. L., Kozhemyakina, R. V., Rasskazov, D. A., Bogomolov, A. G., Kondratyuk, E. Y., Klimova, N. V., Shikhevich, S. G., Ryazanova, M. A., Fedoseeva, L. A., Redina, О. Е., Kozhevnikova, O. S., Stefanova, N. A., Kolosova, N. G., Markel, A. L., Ponomarenko, M. P., & 1 othersOshchepkov, D. Y., Dec 2023, In: Vavilovskii Zhurnal Genetiki i Selektsii. 27, 7, p. 794-806 13 p.

    Research output: Contribution to journal › Article › peer-review

  11. Метаболомный профиль сыворотки крови при экспериментальной артериальной гипертензии

    Seryapina, A. A., Malyavko, A. A., Polityko, Y. K., Yanshole, L. V., Tsentalovich, Y. P. & Markel, A. L., Sept 2023, In: Vavilovskii Zhurnal Genetiki i Selektsii. 27, 5, p. 530-538 9 p.

    Research output: Contribution to journal › Article › peer-review

  12. Age-Dependent Changes in the Relationships between Traits Associated with the Pathogenesis of Stress-Sensitive Hypertension in ISIAH Rats

    Oshchepkov, D. Y., Makovka, Y. V., Ponomarenko, M. P., Redina, O. E. & Markel, A. L., 1 Jul 2023, In: International Journal of Molecular Sciences. 24, 13, 10984.

    Research output: Contribution to journal › Article › peer-review

  13. Animal Models of Hypertension (ISIAH Rats), Catatonia (GC Rats), and Audiogenic Epilepsy (PM Rats) Developed by Breeding

    Ryazanova, M. A., Plekanchuk, V. S., Prokudina, O. I., Makovka, Y. V., Alekhina, T. A., Redina, O. E. & Markel, A. L., Jul 2023, In: Biomedicines. 11, 7, 1814.

    Research output: Contribution to journal › Review article › peer-review

  14. Hypotensive Effects of Arginase Inhibition by L-Norvaline in Genetic Models of Normotensive and Hypertensive Rats

    Gilinsky, M. A., Polityko, Y. K., Markel, A. L. & Aftanas, L. I., 13 Apr 2023, In: Bulletin of Experimental Biology and Medicine. 174, 5, p. 674-677 4 p.

    Research output: Contribution to journal › Article › peer-review

  15. Genes Associated with Increased Stress Sensitivity in Hypertensive ISIAH Rats

    Fedoseeva, L. A., Smolenskaya, S. E., Markel, A. L. & Redina, O. E., Apr 2023, In: Molecular Biology. 57, 2, p. 346-355 10 p.

    Research output: Contribution to journal › Article › peer-review

  16. Differentially Expressed Genes and Molecular Susceptibility to Human Age-Related Diseases

    Shikhevich, S., Chadaeva, I., Khandaev, B., Kozhemyakina, R., Zolotareva, K., Kazachek, A., Oshchepkov, D., Bogomolov, A., Klimova, N. V., Ivanisenko, V. A., Demenkov, P., Mustafin, Z., Markel, A., Savinkova, L., Kolchanov, N. A., Kozlov, V. & Ponomarenko, M., 16 Feb 2023, In: International Journal of Molecular Sciences. 24, 4, 3996.

    Research output: Contribution to journal › Article › peer-review

  17. Гены, ассоциированные с повышенной чувствительностью гипертензивных крыс линии НИСАГ к стрессу

    Fedoseeva, L. A., Smolenskaya, S. E., Markel, A. L. & Redina, O. E., 2023, In: Molekuliarnaia biologiia. 57, 2, p. 362-372 11 p., 21.

    Research output: Contribution to journal › Article › peer-review

  18. 2022

  19. In vivo hypotensive effect of aminosilanol-based nanocomposites bearing antisense oligonucleotides

    Levina, A., Repkova, M., Kupryushkin, M., Seryapina, A., Shevelev, O., Pyshnyi, D., Zarytova, V. & Markel, A., Sept 2022, In: Journal of Drug Delivery Science and Technology. 75, 103612.

    Research output: Contribution to journal › Article › peer-review

  20. 2021

  21. Arginine Metabolism in Hypertensive Rats under Arginase Inhibition by Norvaline

    Gilinsky, M. A., Polityko, Y. K. & Markel, A. L., Jul 2021, In: Journal of Evolutionary Biochemistry and Physiology. 57, 4, p. 945-952 8 p.

    Research output: Contribution to journal › Article › peer-review

  22. Hypothalamic norepinephrine concentration and heart mass in hypertensive isiah rats are associated with a genetic locus on chromosome 18

    Redina, O. E., Smolenskaya, S. E., Polityko, Y. K., Ershov, N. I., Gilinsky, M. A. & Markel, A. L., Jan 2021, In: Journal of Personalized Medicine. 11, 2, p. 1-15 15 p., 67.

    Research output: Contribution to journal › Article › peer-review

  23. 2020

  24. Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension

    Gilinsky, M. A., Polityko, Y. K., Markel, A. L., Latysheva, T. V., Samson, A. O., Polis, B. & Naumenko, S. E., 14 Feb 2020, In: BioMed Research International. 2020, 10 p., 4935386.

    Research output: Contribution to journal › Article › peer-review

  25. Genetic Polymorphism of Experimentally Produced Forms of Arterial Hypertension

    Redina, O. E., Devyatkin, V. A., Ershov, N. I. & Markel, A. L., Feb 2020, In: Russian Journal of Genetics. 56, 2, p. 213-225 13 p.

    Research output: Contribution to journal › Article › peer-review

  26. 2019

  27. Antisense Oligonucleotides Immobilized on Silicon-Organic Nanoparticles as a Tool for Prolonged Correction of Hypertensive States

    Levina, A. S., Repkova, M. N., Klimov, L. O., Ryazanova, M. A., Markel, A. L. & Zarytova, V. F., 15 May 2019, In: Bulletin of Experimental Biology and Medicine. 167, 1, p. 116-119 4 p.

    Research output: Contribution to journal › Article › peer-review

  28. The differences in brain stem transcriptional profiling in hypertensive ISIAH and normotensive WAG rats

    Fedoseeva, L. A., Klimov, L. O., Ershov, N. I., Efimov, V. M., Markel, A. L., Orlov, Y. L. & Redina, O. E., 8 May 2019, In: BMC Genomics. 20, Suppl 3, 16 p., 297.

    Research output: Contribution to journal › Article › peer-review

  29. FTO haplotyping underlines high obesity risk for European populations

    Babenko, V., Babenko, R., Gamieldien, J. & Markel, A., 13 Mar 2019, In: BMC Medical Genomics. 12, Suppl 2, p. 46 9 p., 46.

    Research output: Contribution to journal › Article › peer-review

  30. 2018

  31. Brain as a potential target for antisense oligonucleotide treatment of hypertensive disease. Experimental study on the hypertensive ISIAH rat strain

    Levina, A. S., Zarytova, V. F., Repkova, M. N., Klimov, O. L., Seryapina, A. A., Shikina, N. V., Shevelev, O. B. & Markel, A. L., Dec 2018, In: Basic and Clinical Pharmacology and Toxicology. 124, p. 6-7 2 p.

    Research output: Contribution to journal › Meeting Abstract › peer-review

  32. ANTISENSE CONTAINING NANOCOMPOSITES IN HYPERTENSION TREATMENT IN ISIAH RATS

    Klimov, L., Ryazanova, M., Levina, A. & Markel, A., Oct 2018, In: Journal of Hypertension. 36, p. E18-E18 1 p.

    Research output: Contribution to journal › Meeting Abstract › peer-review

  33. NANOCOMPOSITE (SI-ODN-II), CONTAINING ANTISENSE OLIGONUCLEOTIDES TARGETED TO MRNA OF THE BETA-1-ADRENORECEPTORS FOR HYPERTENSION THERAPY IN RATS WITH STRESS-SENSITIVE ARTERIAL HYPERTENSION (ISIAH RATS)

    Ryazanova, M., Klimov, L., Seryapina, A., Zarytova, V., Repkova, M., Levina, A. & Markel, A., Oct 2018, In: Journal of Hypertension. 36, p. E81-E82 2 p.

    Research output: Contribution to journal › Meeting Abstract › peer-review

  34. Stress, Genes, and Hypertension. Contribution of the ISIAH Rat Strain Study

    Redina, O. E. & Markel, A. L., 16 Jun 2018, In: Current Hypertension Reports. 20, 8, 10 p., 66.

    Research output: Contribution to journal › Review article › peer-review

  35. GC-based chemoprofile of lipophilic compounds in Altaian Ganoderma lucidum sample

    Shevelev, O. B., Seryapina, A. A., Zavjalov, E. L., Gerlinskaya, L. A., Goryachkovskaya, T. N., Slynko, N. M., Kuibida, L. V., Peltek, S. E., Markel, A. L. & Moshkin, M. P., 1 Jun 2018, In: Data in Brief. 18, p. 1054-1056 3 p.

    Research output: Contribution to journal › Article › peer-review

  36. Epigenetic Mechanisms of Blood-Pressure Regulation

    Markel, A. L. & Redina, O. E., 27 Apr 2018, In: Molekuliarnaia biologiia. 52, 2, p. 172-189 18 p.

    Research output: Contribution to journal › Review article › peer-review

  37. Epigenetic Mechanisms of Blood-Pressure Regulation

    Markel, A. L. & Redina, O. E., 1 Mar 2018, In: Molecular Biology. 52, 2, p. 151-164 14 p.

    Research output: Contribution to journal › Review article › peer-review

  38. Hypotensive and neurometabolic effects of intragastric Reishi (Ganoderma lucidum) administration in hypertensive ISIAH rat strain

    Shevelev, O. B., Seryapina, A. A., Zavjalov, E. L., Gerlinskaya, L. A., Goryachkovskaya, T. N., Slynko, N. M., Kuibida, L. V., Peltek, S. E., Markel, A. L. & Moshkin, M. P., 1 Mar 2018, In: Phytomedicine. 41, p. 1-6 6 p.

    Research output: Contribution to journal › Article › peer-review

  39. The Biosocial Bases of Aggressivity and Aggressive Behavior

    Markel’, A. L., 1 Mar 2018, In: Neuroscience and Behavioral Physiology. 48, 3, p. 251-260 10 p.

    Research output: Contribution to journal › Article › peer-review

  40. Antisense oligonucleotides for the arterial hypertension mechanisms study and therapy

    Klimov, L. O., Seryapina, A. A., Zarytova, V. F., Levina, A. S. & Markel, A. L., 1 Jan 2018, In: Вавиловский журнал генетики и селекции. 22, 2, p. 240-247 8 p.

    Research output: Contribution to journal › Review article › peer-review

  41. Genetics and pathophysiology of low-renin arterial hypertension

    Markel, A. L., 1 Jan 2018, In: Вавиловский журнал генетики и селекции. 22, 8, p. 1000-1008 9 p.

    Research output: Contribution to journal › Review article › peer-review

  42. 2017

  43. Differential alternative splicing in brain regions of rats selected for aggressive behavior

    Babenko, V. N., Bragin, A. O., Chadaeva, I. V., Markel, A. L. & Orlov, Y. L., 9 Nov 2017, In: Molekuliarnaia biologiia. 51, 5, p. 870-880 11 p.

    Research output: Contribution to journal › Article › peer-review

  44. Differential alternative splicing in brain regions of rats selected for aggressive behavior

    Babenko, V. N., Bragin, A. O., Chadaeva, I. V., Markel, A. L. & Orlov, Y. L., 1 Sept 2017, In: Molecular Biology. 51, 5, p. 759-768 10 p.

    Research output: Contribution to journal › Article › peer-review

  45. Soluble epoxide hydrolase (sEH) as a potential target for arterial hypertension therapy

    Redina, O. E., Abramova, T. O., Klimov, L. O., Ryazanova, M. A., Fedoseeva, L. A., Smolenskaya, S. E., Ershov, N. I., Dubinina, A. D. & Markel, A. L., 1 Sept 2017, In: Russian Journal of Genetics. 53, 9, p. 972-981 10 p.

    Research output: Contribution to journal › Article › peer-review

  46. Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension

    Abramova, T. O., Ryazanova, M. A., Antonov, E. V., Redina, O. E. & Markel, A. L., 1 May 2017, In: Molecular Biology. 51, 3, p. 389-392 4 p.

    Research output: Contribution to journal › Article › peer-review

  47. Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension

    Abramova, T. O., Ryazanova, M. A., Antonov, E. V., Redina, O. E. & Markel, A. L., 1 May 2017, In: Molekuliarnaia biologiia. 51, 3, p. 442-446 5 p.

    Research output: Contribution to journal › Article › peer-review

  48. Stress-sensitive arterial hypertension, haemodynamic changes and brain metabolites in hypertensive ISIAH rats: MRI investigation

    Seryapina, A. A., Shevelev, O. B., Moshkin, M. P., Markel, A. L. & Akulov, A. E., 1 May 2017, In: Experimental Physiology. 102, 5, p. 523-532 10 p.

    Research output: Contribution to journal › Article › peer-review

  49. Quercetin Attenuates Benzo(α)pyrene-induced CYP1A Expression

    Perepechaeva, M. L., Seredina, T. A., Sidorova, Y. A., Pivovarova, E. N., Markel, A. L., Lyakhovich, V. V. & Grishanova, A. Y., 1 Apr 2017, In: Biomedical and Environmental Sciences. 30, 4, p. 308-313 6 p.

    Research output: Contribution to journal › Article › peer-review

  50. Toward gene therapy of hypertension: Experimental study on hypertensive ISIAH rats

    Repkova, M. N., Levina, A. S., Seryapina, A. A., Shikina, N. V., Bessudnova, E. V., Zarytova, V. F. & Markel, A. L., 1 Apr 2017, In: Biochemistry (Moscow). 82, 4, p. 454-457 4 p.

    Research output: Contribution to journal › Article › peer-review

  51. Strain-specific single-nucleotide polymorphisms in hypertensive ISIAH rats

    Ershov, N. I., Markel, A. L. & Redina, O. E., 1 Feb 2017, In: Biochemistry (Moscow). 82, 2, p. 224-235 12 p.

    Research output: Contribution to journal › Article › peer-review

  52. On the human nature (following in the steps of Belyaev)

    Markel, A. L., 1 Jan 2017, In: Вавиловский журнал генетики и селекции. 21, 4, p. 492-500 9 p.

    Research output: Contribution to journal › Review article › peer-review

  53. Role of apoptosis genes in aggression revealed using combined analysis of ANDSystem gene networks, expression and genomic data in grey rats with aggressive behavior

    Bragin, A. O., Saik, O. V., Chadaeva, I. V., Demenkov, P. S., Markel, A. L., Orlov, Y. L., Rogaev, E. I., Lavrik, I. N. & Ivanisenko, V. A., 1 Jan 2017, In: Вавиловский журнал генетики и селекции. 21, 8, p. 911-919 9 p.

    Research output: Contribution to journal › Article › peer-review

  54. Effects of brain reninangiotensin system inhibition in ISIAH rats with inherited stress-induced arterial hypertension

    Klimov, L. O., Ryazanova, M. A., Fedoseeva, L. A. & Markel, A. L., 2017, In: Вавиловский журнал генетики и селекции. 21, 6, p. 735-741 7 p.

    Research output: Contribution to journal › Article › peer-review

  55. Essential systemic hypertension: Genetics, clinics, experiment

    Markel, A. L., 2017, In: Russian Journal of Cardiology. 150, 10, p. 133-139 7 p.

    Research output: Contribution to journal › Article › peer-review

  56. 2012

  57. ПРЕПАРАТ, СНИЖАЮЩИЙ ВРЕМЯ КАТАЛЕПТИЧЕСКИХ РЕАКЦИЙ, ТРЕВОЖНОСТЬ И УСИЛИВАЮЩИЙ ИССЛЕДОВАТЕЛЬСКУЮ МОТИВАЦИЮ

    Болдырев, В. В., Болдырева, Е. В., Ачкасов, А. Ф. & Маркель, А. Л., 20 Apr 2012, IPC No. A61K31/195, A61P25/28, A61P25/00, Роспатент - Федеральная служба по интеллектуальной собственности, Patent No. 2447890, Priority date 20 Oct 2010, Priority No. 2010143182

    Research output: Patent › Patent for invention

ID: 3449824